Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1120)
DME Name Glutamate racemase (MurI), Aquifex pyrophilus
Synonyms D-glutamate racemase; MurI; murI; BAS0806; BAS4379; BcGR; BsGR; BsRacE; DapF; FnGR; GBAA_0847; GBAA_4717
Gene Name murI
UniProt ID
MURI_AQUPY
EC Number    EC: 5.1.1.3     (Click to Show/Hide the Complete EC Tree)
Isomerase
Racemase/epimerase
Amino acid racemase/epimerase
EC: 5.1.1.3
Lineage    Species: Aquifex pyrophilus     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Aquificae
Class: Aquificae
Order: Aquificales
Family: Aquificaceae
Genus: Aquifex
Species: Aquifex pyrophilus
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MKIGIFDSGVGGLTVLKAIRNRYRKVDIVYLGDTARVPYGIRSKDTIIRYSLECAGFLKD
KGVDIIVVACNTASAYALERLKKEINVPVFGVIEPGVKEALKKSRNKKIGVIGTPATVKS
GAYQRKLEEGGADVFAKACPLFVPLAEEGLLEGEITRKVVEHYLKEFKGKIDTLILGCTH
YPLLKKEIKKFLGDVEVVDSSEALSLSLHNFIKDDGSSSLELFFTDLSPNLQFLIKLILG
RDYPVKLAEGVFTH
Structure
1B73 ; 1B74
Function This enzyme is a pyridoxal-phosphate protein providing the (R)-glutamate required for cell wall biosynthesis and converting L- or D-glutamate to D- or L-glutamate, respectively, but not other amino acids such as alanine, aspartate, and glutamine.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
L-glutamine
 Drug Info Approved Sickle-cell anaemia ICD11: 3A51 [1]
      Experimental Enzyme Kinetic Data of Drugs Click to Show/Hide the Full List of Drugs:          1 Drugs
L-glutamine
 Drug Info Approved Sickle-cell anaemia Km = 3300 microM [1]
References
1 Structural and functional analysis of two glutamate racemase isozymes from Bacillus anthracis and implications for inhibitor design. J Mol Biol. 2007 Aug 31;371(5):1219-37.

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