Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1177)
DME Name Inositol dehydrogenase (idh), Lactobacillus casei
Synonyms Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase; Myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase; MI 2-dehydrogenase/DCI 3-dehydrogenase; LCABL_02210; idh
Gene Name idh
UniProt ID
A0A0J9X1Y2_LACCB
EC Number    EC: 1.1.1.18     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.18
Lineage    Species: Lactobacillus casei     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus casei
Subspecies: Lactobacillus casei BL23
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MVVKVGVIGTGAMGRAHIDRLTNVLTGAEVVAVTDIDHEAAEAAVRDFHLNAKVYPDDTS
LLQDPDIDAVFVVSFGGAHEATVLKALDTDKFIFTEKPLATTLEGAKRIVDKELTKSKKV
IQVGFMRRYDQGIRALKEKLDTGIIGAPLVVRASHINPNVASNYSNEMAITDTLIHEIDE
MHWLLDDEYTSIQITYPRQSAEVRNEGLHDPQLATLTTKKGTVIQVLVHVTAQYGYEVKL
EVIGETGELQLPNYGLGPILRSNANQQTAVEMSWINRFIQAYNTEVQEFIDEVAKSEPPV
GPSAWDGYIAAITAAAANRSQKDQETVLINVAGTPTFYQ
Structure
4MIE ; 4MIN ; 4MIO ; 4MIY ; 4MJL
Function This enzyme involves in the oxidation of myo-inositol and D-chiro-inositol to 2-keto-myo-inositol and 1-keto-D-chiro-inositol, respectively.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Inositol
 Drug Info Phase 4 Polycystic ovary syndrome ICD11: 5A80 [1]
References
1 Purification, crystallization and room-temperature X-ray diffraction of inositol dehydrogenase LcIDH2 from Lactobacillus casei BL23. Acta Crystallogr F Struct Biol Commun. 2014 Jul;70(Pt 7):979-83.

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