Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1179)
DME Name Linoleate isomerase (lai), Butyrivibrio fibrisolvens
Synonyms Linoleic acid isomerase; C12 isomerase; LA isomerase; Linoleate DELTA12-cis/DELTA11-trans isomerase; Linoleic acid DELTA12-cis/DELTA11-trans-isomerase; LA-I; LAI; LAI12
Gene Name lai
UniProt ID
D2BQ64_LACLK
EC Number    EC: 5.2.1.5     (Click to Show/Hide the Complete EC Tree)
Isomerase
Cis-trans-isomerase
Cis-trans isomerase
EC: 5.2.1.5
Lineage    Species: Butyrivibrio fibrisolvens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Lachnospiraceae
Genus: Butyrivibrio
Species: Butyrivibrio fibrisolvens
Subspecies: Butyrivibrio fibrisolvens A38
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut and stomach.
Sequence
MRYTNGNYEAFVHPRKPENVDQKSAYIIGAGLAGLATAVFLIRDGQMSGDRIHILEELPL
SGGSLDGSFIPHDGFVVRGGREMENHFECLWDLFRTIPSLEVDNASVLDEFYRIDRDDPN
SSNCRIIHNRGERVDDDGKFTLSPKAQEEIIKLFMTKEELLVGKTIEDCFTDEFFESNFW
LYWCSMFAFEKWHSAIEMRRYIMRFIHHIEGLPDFSALKFTKYNQYESLVKPLISYLKDH
GVDFKYGAQVENVEVDFSNGKKVAKAIVFADKKIKELTENDLVFVTNGSITESSTQGSPT
QAAPKTSELGGSWKLWQNLAKQSEEFGHPDVFCKDIPKETWVVSATVTWENLKIQPYFEK
LTHRQLRSGKVVTGGIITVKDSNWLLSFTTHRQPHFKEQNDQETVTWVYGLLSNTPGNYI
KKPIEDCTGEEITQELLYHLGMPEEEIEAFVKENTNTIPVYMPFITSYFMLREPGDRPLV
VPEQSVNLAFLGNFAETERDTVFTTEYSVRTAMEAVYQLLNVDRGVPEVYASAYDLRTLA
SSAYYLSDKQKLEDLELSFIKKQALKVGLKKIKGTYIEELLEDAGLI
Function This enzyme takes part in linoleic acid metabolism and catalyzes the conversion of 9-cis,12-cis-octadecadienoate to 9-cis,11-trans-octadecadienoate.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Unifac-6550
 Drug Info Phase 1 Obesity ICD11: 5B81 [1], [2]
References
1 Cell-associated alpha-amylases of butyrate-producing Firmicute bacteria from the human colon. Microbiology. 2006 Nov;152(Pt 11):3281-3290.
2 Effect of linoleic acid concentration on conjugated linoleic acid production by Butyrivibrio fibrisolvens A38. Appl Environ Microbiol. 2000 Dec;66(12):5226-30.

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