Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1193)
DME Name Beta-glucuronidase (uidA), Bacteroides uniformis
Synonyms Beta-galactosidase/beta-glucuronidase; Beta-galactosidase BgaB; ERS852462_01204; ERS852510_02901; uidA_1; uidA_2
Gene Name uidA_1
UniProt ID
A0A174H0E7_BACUN
EC Number    EC: 3.2.1.31     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.31
Lineage    Species: Bacteroides uniformis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Bacteroidaceae
Genus: Bacteroides
Species: Bacteroides uniformis
Subspecies: Bacteroides uniformis str. 3978 T3 i
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MITCLLAVSVLGGKSQAQDLLSNVYGRDYQLLNGKWGAIVDLYDQGERMQVYKNRKPQDN
KQFYEYSFDGGLVLNVPADFNSQMPELKFYEGTVWYGRSFDTPKTDGKRLFLYFGAVSYR
SKIYLNGEKIASHEGGFTPFQVEITDKVKQKDNFLVVKVNNTRTTDAIPAMSFDWWNYGG
ITRDVMLVSVPQSYIKDHFIQLDKVQSNLIRAKVTLSEAKPGINVQVAIPELGIRQNMTT
DANGIAQATIKTKKLQRWSPDAPKLYDVTITSESDRLNEQIGFRNLYVKGEDIYLNDQPI
FLRSISFHEEIPQRRGRAFSEADATMLLSEAKELGANMIRLAHYPQNEYTVRLAERMGFL
LWEEIPIWQGIDFKNTATREKAGRMIKEMVMRDKNRCSVAFWGIANETATSAPRNEFLKH
MKQCCLDIDSTRLITAAFDLVRFNRESRDFEMNDSIINILDMVAINKYMGWYHDWPLAPD
QAVWNVAPGKPLFISEFGGEALYGKHGDAEVKSSWSEDYQAQLYKDNLEMFKHIPNLRGT
SPWILLDFRSPFRFHPHQGGEWNRKGLVSDQGQRKKAWYIMRDYYNQKKTEQ
Function This enzyme takes part in glucuronoside catabolic process. It catalyzes the hydrolysis of beta-glucuronide containing substrates.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          2 Drugs
MUG trihydrate
 Drug Info Investigative Discovery agent ICD: N.A. [1]
SN-38G
 Drug Info Investigative Colorectal cancer ICD11: 2B91 [1]
      Experimental Enzyme Kinetic Data of Drugs Click to Show/Hide the Full List of Drugs:          1 Drugs
MUG trihydrate
 Drug Info Investigative Discovery agent Km = 25 microM [1]
References
1 Three structurally and functionally distinct beta-glucuronidases from the human gut microbe Bacteroides uniformis. J Biol Chem. 2018 Nov 30;293(48):18559-18573.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.