Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1194)
DME Name Beta-glucuronidase (uidA), Bacteroides thetaiotaomicron
Synonyms Beta-galactosidase/beta-glucuronidase; Beta-galactosidase BgaB; ERS852554_01806; uidA_2
Gene Name uidA_2
UniProt ID
A0A174R8A7_BACUN
EC Number    EC: 3.2.1.31     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.31
Lineage    Species: Bacteroides thetaiotaomicron     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Bacteroidaceae
Genus: Bacteroides
Species: Bacteroides thetaiotaomicron
Subspecies: Bacteroides thetaiotaomicron str. 3978 T3 i
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MITCLLTVSVLGGKSQAQDLLSNVYGRDYRLLNGKWGAIVDLYDQGERMQVYKNRKPQDN
KQFYEYSFDGGLVLNVPADFNSQMPELKFYEGTVWYGRSFDTPKTDGKRLFLYFGAVSYR
SKIYLNGEKIASHEGGFTPFQVEITDKVKQKDNFLVVKVNNTRTTDAIPAMSFDWWNYGG
ITRDVMLVSVPQSYIKDHFIQLDKVQSNLIRAKVTLSEAKPGINVQVAIPELGIRQNMTT
DANGIARATIKTKKLQRWSPDAPKLYDVTITSESDRLNEQIGFRNLYVKGEDIYLNDRPI
FLRSVSFHEEIPQRRGRAFSEADATMLLSEAKELGANMIRLAHYPQNEYTVRLAERMGFL
LWEEIPIWQGIDFKNTATREKAGRMIKEMVMRDKNRCSVAFWGIANETATSTPRNEFLKH
MKQCCLDIDSTRLITAAFDLVRFNRESRNFEMNDSIINILDMVAINKYMGWYHDWPLAPD
QAVWNVAPGKPLFISEFGGEALYGKHGDAEVKSSWSEDYQAQLYKDNLEMFKHIPNLRGT
SPWILFDFRSPFRFHPHQGGEWNRKGLVSDQGQRKKAWYIMRDYYNQKKTEQ
Function This enzyme takes part in glucuronoside catabolic process. It catalyzes the hydrolysis of beta-glucuronide containing substrates.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          2 Drugs
MUG trihydrate
 Drug Info Investigative Discovery agent ICD: N.A. [1]
SN-38G
 Drug Info Investigative Colorectal cancer ICD11: 2B91 [1]
      Experimental Enzyme Kinetic Data of Drugs Click to Show/Hide the Full List of Drugs:          1 Drugs
MUG trihydrate
 Drug Info Investigative Discovery agent Km = 80 microM [1]
References
1 Three structurally and functionally distinct beta-glucuronidases from the human gut microbe Bacteroides uniformis. J Biol Chem. 2018 Nov 30;293(48):18559-18573.

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