Details of Drug-Metabolizing Enzyme (DME)
General Information of DME (ID: DME1211) | |||||
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DME Name | Beta-glucuronidase (uidA), Lactobacillus rhamnosus | ||||
Synonyms | Beta-galactosidase/beta-glucuronidase; Beta-galactosidase BgaB; BGK71_00200; CCE29_06935; FEZ43_12625; NCTC13710_00049; PY91_01090; uidA | ||||
Gene Name | uidA | ||||
UniProt ID | |||||
Gene ID | |||||
EC Number | EC: 3.2.1.31 (Click to Show/Hide the Complete EC Tree) | ||||
Lineage | Species: Lactobacillus rhamnosus (Click to Show/Hide the Complete Species Lineage) | ||||
Interactome(loading-time for this interactome depdends on the speed of web connection) | |||||
Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME | |||||
Tissue Distribution | Primarily distributed in human gut. | ||||
Sequence |
METSLLYPVTNDQRTDQKLDGLWQFKFDEAGEGEKSGWETGFHDGVSMPVPASFNDFFTD
KASREYTGDFWYSRNFFVPSAAKGKALFLRFDAVTHRATIFVNGKEIRTHEGGFLPFAAD ISEAVKYGAENTVVVKGNNELSREALPAGDTITLRNGKKMVRPFFDFYNYSGLNRSVHLL SLPQERVLDYTTTFALAGNDATVNYTVETNGDAPVTVSLADADGQVVATAQGKQGALQVQ NAHLWQVRNAYLYTLTIQLGDDTQTPLDTYTDRIGIRTIKISGTDILVNDKPIYLKGFGR HEDSPFAGRAFDLNVEKKDFALMKWIGANSFRTSHYPYDEQVYKIADEEGFLLTDEVPAV GFKMAAAAFLGGLNQSFFKGPWLKKLHERHIDQIRDLIKRDKNHPSVLAWSLFNEPDTID ENAVPYFKQIFDESKDLDPQGRPRTFTLSEDDTIETSKVLDFPDFYMLNRYPGWYHFGGY QISDGEAGLRDEMDKWQKAGVKKPVVFTEFGADTEAGLHKLPSVMWTEEYQVEVLKMFSR VFDDYDFIKGEQVWNLADFQTVEGNMRVNGNKKGIFTRDRQPKAAAFFYHDRWNKLPLDY KAK |
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Structure | |||||
Function | This enzyme takes part in glucuronoside catabolic process. It catalyzes the hydrolysis of beta-glucuronide containing substrates. | ||||
Full List of Drug(s) Metabolized by This DME | |||||
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Preclinical/investigative Agents | Click to Show/Hide the Full List of Drugs: 1 Drugs | ||||
Diclofenac glucuronide |
Drug Info | Investigative | Discovery agent | ICD: N.A. | [1] |
References | |||||
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1 | tructure, function, and inhibition of drug reactivating human gut microbial beta-glucuronidases. Sci Rep. 2019 Jan 29;9(1):825. |
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