Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1217)
DME Name Beta-lactamase (blaB), Parabacteroides merdae
Synonyms Penicillinase; Cephalosporinase; Beta-lactam; cfxA; DW828_01985
Gene Name cfxA
UniProt ID
A0A414C8Y0_9BACT
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Parabacteroides merdae     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Tannerellaceae
Genus: Parabacteroides
Species: Parabacteroides merdae
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MEKNRKKQIVVLSIALVCIFILVFSLFHKSATKDSANPPLTNVLTDSISQIVSACPGEIG
VAVIVNNRDTVKVNNKSVYPMMSVFKVHQALALCNDFDNKGISLDTLVNINRDKLDPKTW
SPMLKDYSGPVISLTVRDLLRYTLTQSDNNASNLMFKDMVNVAQTDSFIATLIPRSSFQI
AYTEEEMSADHNKAYSNYTSPLGAAMLMNRLFTEGLIDDEKQSFIKNTLKECKTGVDRIA
APLLDKEGVVIAHKTGSGYVNENGVLAAHNDVAYICLPNNISYTLAVFVKDFKGNESQAS
QYVAHISAVVYSLLMQTSVKS
Function This enzyme hydrolyzes beta-lactam.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          2 Drugs
Cefotaxime
 Drug Info Approved Meningitis ICD11: 1A62 [1]
Cefoxitin
 Drug Info Approved Peritonitis ICD11: DC50 [1]
References
1 Presence of the cfxA gene in Bacteroides distasonis. Res Microbiol. 2003 Jun;154(5):369-74.

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