Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1249)
DME Name S-(hydroxymethyl)glutathione dehydrogenase (adh), Vibrio cholerae
Synonyms NAD- and glutathione-dependent formaldehyde dehydrogenase; NAD-dependent formaldehyde dehydrogenase; NAD-linked formaldehyde dehydrogenase; Class III alcohol dehydrogenase; Formaldehyde dehydrogenase; Formaldehyde dehydrogenase (glutathione); Formic dehydrogenase; GD-FALDH; GS-FDH; adh
Gene Name adh
UniProt ID
A0A0A7DS01_VIBCL
Gene ID
39724692
EC Number    EC: 1.1.1.284     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.284
Lineage    Species: Vibrio cholerae     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Vibrionales
Family: Vibrionaceae
Genus: Vibrio
Species: Vibrio cholerae
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MKSRAAVAFGPGLPLEIVEIDVAPPKKGEVLVKISHTGVCHTDAYTLSGDDPEGLFPVVL
GHEGAGVVVEVGEGVTSVKPGDHVIPLYTAECGECDFCTSGKTNLCVAVRETQGKGVMPD
GTSRFSYNGQPLYHYMGCSTFSEYTVVAEVSLAKINPQANAEQVCLLGCGVTTGIGAVHN
TAKVQEGDSVAVFGLGGIGLAVVQGARQAKAGRIFAIDTNPSKFELAKQFGATDCINPND
YDKPVQQVLVEMTKWGVDHTFECIGNVNVMRSALESAHRGWGQSVIIGVAGAGKEISTRP
FQLVTGRVWKGTAFGGVKGRTQLPGMVEDAMSGKIELAPFVTHTMELDKINEAFDLMHDG
KSIRTVIHY
Function This enzyme specifically reduces S-(hydroxymethyl)glutathione.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          4 Drugs
Regorafenib
 Drug Info Approved Colon cancer ICD11: 2B90 [1]
Methadone
 Drug Info Approved Anaesthesia ICD11: 8E22 [2]
Nitroprusside
 Drug Info Approved Congestive heart failure ICD11: BD10 [3]
Ethambutol
 Drug Info Approved Pulmonary tuberculosis ICD11: 1B10-1B12 [4]
      Drugs in Phase 2 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Phenylbutyrate
 Drug Info Phase 2 Phenylketonuria ICD11: 5C50 [5]
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
HSDB-674
 Drug Info Phase 1 Rheumatoid arthritis ICD11: FA20 [6]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          2 Drugs
SC-47945
 Drug Info Investigative Discovery agent ICD: N.A. [7]
Nitrosoglutathione
 Drug Info Investigative Discovery agent ICD: N.A. [3]
References
1 Mass balance, metabolic disposition, and pharmacokinetics of a single oral dose of regorafenib in healthy human subjects
2 Effects of cytochrome P450 single nucleotide polymorphisms on methadone metabolism and pharmacodynamics
3 Nitrosative stress response in Vibrio cholerae: role of S-nitrosoglutathione reductase. Appl Biochem Biotechnol. 2017 Jul;182(3):871-884.
4 COMPARATIVE METABOLISM OF ETHAMBUTOL AND ITS L-ISOMER
5 New secondary metabolites of phenylbutyrate in humans and rats
6 Oxidation of secondary alcohols to methyl ketones by yeasts
7 Neurotoxicity and metabolism of the catecholamine-derived 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylglycolaldehyde: the role of aldehyde dehydrogenase. Pharmacol Rev. 2007 Jun;59(2):125-50.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.