Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1253)
DME Name Unclear metabolic mechanism (DME-unclear), Bacteroides oleiciplenus
Gene Name DME-unclear
Lineage    Species: Bacteroides oleiciplenus     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Bacteroidaceae
Genus: Bacteroides
Species: Bacteroides oleiciplenus
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Omeprazole
 Drug Info Approved Gastro-oesophageal reflux disease ICD11: DA22 [1]
      Drugs in Phase 3 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
BV-ara-U
 Drug Info Phase 3 Human immunodeficiency virus infection ICD11: 1C60 [2]
      Drugs in Phase 2 Clinical Trial Click to Show/Hide the Full List of Drugs:          2 Drugs
HY-N0669
 Drug Info Phase 2 Essential hypertension ICD11: BA00 [3]
Q-100154
 Drug Info Phase 2 Hepatocellular carcinoma ICD11: 2C12 [4]
      Discontinued/withdrawn Drugs Click to Show/Hide the Full List of Drugs:          1 Drugs
Levamisole
 Drug Info Discontinued Ascariasis ICD11: 1F62 [5]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          5 Drugs
Liquiritin
 Drug Info Investigative Rheumatoid arthritis ICD11: FA20 [6]
Kalopanaxsaponin H
 Drug Info Investigative Diabetes mellitus ICD11: 5A10 [7]
Kalopanaxsaponin I
 Drug Info Investigative Prostate cancer ICD11: 2C82 [7]
Kalopanaxsaponin K
 Drug Info Investigative Rheumatoid arthritis ICD11: FA20 [7]
Ginsenoside Rh2
 Drug Info Investigative Breast cancer ICD11: 2C60 [8]
References
1 Metabolism of omeprazole by gut flora in rats. J Pharm Sci. 1995 Apr;84(4):516-7. Letter
2 Intestinal anaerobic bacteria hydrolyse sorivudine, producing the high blood concentration of 5-(E)-(2-bromovinyl)uracil that increases the level and toxicity of 5-fluorouracil. Pharmacogenetics. 1997 Feb;7(1):35-43.
3 Microbial hydrolysis of steviol glycosides. Food Chem Toxicol. 2008 Jul;46 Suppl 7:S70-4.
4 Interactions between various microbes and ginseng botanicals. Crit Rev Microbiol. 2011 May;37(2):113-20.
5 Metabolism of levamisole, an anti-colon cancer drug, by human intestinal bacteria. Xenobiotica. 1991 Jun;21(6):737-50.
6 Effect of liquiritin on human intestinal bacteria growth: metabolism and modulation. Biomed Chromatogr. 2014 Sep;28(9):1271-7.
7 Metabolism of kalopanaxsaponin K by human intestinal bacteria and antirheumatoid arthritis activity of their metabolites. Biol Pharm Bull. 2002 Jan;25(1):68-71.
8 Metabolism of 20(S)- and 20(R)-ginsenoside Rg3 by human intestinal bacteria and its relation to in vitro biological activities. Biol Pharm Bull. 2002 Jan;25(1):58-63.

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