Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1297)
DME Name VanC2 ligase (vanC), Enterococcus casseliflavus
Synonyms Vancomycin C-type resistance protein VanC; VanC ligase; vanC; vanC-2; vanC2; NCTC12361_02496
Gene Name vanC-2
UniProt ID
Q47720_ENTCA
EC Number    EC: 6.3.2.4     (Click to Show/Hide the Complete EC Tree)
Ligase
Carbon-nitrogen ligase
Peptide synthase
EC: 6.3.2.4
Lineage    Species: Enterococcus casseliflavus     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Enterococcaceae
Genus: Enterococcus
Species: Enterococcus casseliflavus
Subspecies: Enterococcus casseliflavus ATCC 25788
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MKKIAIIFGGNSPEYTVSLASATSAIEALQSSPYDYDLSLIGIAPDAMDWYLYTGELENI
RQDTWLLDTKHKQKIQPLFEGNGFWLSEEQQTLVPDVLFPIMHGKYGEDGSIQGLFELMK
LPYVGCGVAGSALCMNKWLLHQAAAAIGVQSAPTILLTNQANQQEQIEAFIQTHGFPVFF
KPNEAGSSKGITKVTCVEEIASALKEAFTYCSAVLLQKNIAGVEIGCGILGNDSLTVGAC
DAISLVDGFFDFEEKYQLISAKITVPAPLPETIETKVKEQAQLLYRSLGLKGLARIDFFV
TERGELYLNEINTMPGFTSHSRYPAMMAAVGLSYQELLQKLLVLAKEEVK
Function This enzyme is involved with UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---L-lysine ligase (EC 6.3.2.7) or UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---2,6-diaminopimelate ligase (EC 6.3.2.13), UDP-N-acetylmuramate---L-alanine ligase (EC 6.3.2.8), UDP-N-acetylmuramoyl-L-alanine---D-glutamate ligase (EC 6.3.2.9) and UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase (EC 6.3.2.10) in the synthesis of a cell-wall peptide.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Vancomycin
 Drug Info Approved Methicillin-resistant staphylococcus infection ICD11: 1D01 [1]
References
1 Bacterial resistance to vancomycin: overproduction, purification, and characterization of VanC2 from Enterococcus casseliflavus as a D-Ala-D-Ser ligase. Proc Natl Acad Sci U S A. 1997 Sep 16;94(19):10040-4.

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