Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1313)
DME Name Beta-lactamase (blaB), Holdemanella biformis
Synonyms Penicillinase; Cephalosporinase; Beta-lactam; EUBIFOR_00490
Gene Name blaB
UniProt ID
B7C8I6_9FIRM
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Holdemanella biformis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Erysipelotrichia
Order: Erysipelotrichales
Family: Erysipelotrichaceae
Genus: Holdemanella
Species: Holdemanella biformis
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MQNGKIVCADAIGVIDKINNQPITTDCTFNVCSISKIYCTVCIMQLVDEGLIQLEDKVAD
ILPEFTMKDERYKDITVRMCLDHSSGLPGTQWKHFSVSTTSKFDYYSEVLNYFSNSTLKA
DPGTYSTYCNDGFTLAEMVVSKVRNMPYEDVLKKYITEKIGAKSTNTTYTINSDCPLVSE
GKKPKEYFPIQGAGGITTSMIDLCKFGQLFLEPNSIISEKSKTLMAKSWGTTFLESDLGA
IDFGLGWDLVRHHDPDYDFGDGVLAKGGNSMFFSSRLIIVPKYNAVLAFSETHDCGLEVP
TTLMRLFNTYLEPNTYPDYSGIYAHAFGLQKITTIKSSMVVQDKTEKGWIMSDLLNYSNG
KWTNEKGNQIFFEGDYLLKTTRNRTGAFAQKAKKQELNSVWKSRLNKKYIVCDTTYYDIV
TNQMLCSVEFNRTEDTLSLIVHGNKSEPVISEFPIEVIDDTHAKSYLNTPCNGSRDRIEP
YFEDGKLYCASYTYICEDDIEPYNFQLFEKENQVYKINNTLEVLPTICENHRILVLDSNG
DLYYDSMDVEEYKPIESGFIILV
Function This enzyme hydrolyzes beta-lactam.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Ceftiofur
 Drug Info Investigative Superficial thrombophlebitis ICD11: BD70 [1], [2]
References
1 Bovine intestinal bacteria inactivate and degrade ceftiofur and ceftriaxone with multiple beta-lactamases. Antimicrob Agents Chemother. 2011 Nov;55(11):4990-8.
2 Daily HIV pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate-emtricitabine reduced Streptococcus and increased Erysipelotrichaceae in rectal microbiota. Sci Rep. 2018 Oct 12;8(1):15212.

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