Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1322)
DME Name Azoreductase (azoR), Lactobacillus buchneri
Synonyms Azo-dye reductase; FMN-dependent NADH-azo compound oxidoreductase; FMN-dependent NADH-azoreductase; azoR; DCW31_09905
Gene Name azoR
UniProt ID
A0A349MYB4_9LACO
EC Number    EC: 1.7.1.6     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Cytochrome acceptor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.7.1.6
Lineage    Species: Lactobacillus buchneri     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus buchneri
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MAKILVIKAHPLTIEHSRTLKILDAFMTQYKVSNPEDTIETRDLYAEEFPDIDRSMMTAW
GQLQNGVGFPDLTTQQQQQLSAYDSTTQQYIDADKVILANPMWNLSIPAKLQAWIDTICV
AGKTFQYTETAEIPLVPGKKVLHIQTAGGFYDGKDFGAKYISGIMHFLGASDVQELAVEG
MDHFPEKAEAFMQDGLERATALATKF
Function This enzyme catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. And it requires NADH, but not NADPH, as an electron donor for its activity.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Sulfasalazine
 Drug Info Approved Rheumatoid arthritis ICD11: FA20 [1]
References
1 The role of intestinal bacteria in the metabolism of salicylazosulfapyridine. J Pharmacol Exp Ther. 1972 Jun;181(3):555-62.

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