Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1337)
DME Name D-alanylalanine synthetase (ddl), Roseburia intestinalis
Synonyms Alanylalanine synthetase; D-D-Ala-D-Ala ligase; D-D-alanine--D-alanine ligase; DW856_04795; BHW46_13680
Gene Name ddl
UniProt ID
A0A1Q6S944_9FIRM
EC Number    EC: 6.3.2.4     (Click to Show/Hide the Complete EC Tree)
Ligase
Carbon-nitrogen ligase
Peptide synthase
EC: 6.3.2.4
Lineage    Species: Roseburia intestinalis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Lachnospiraceae
Genus: Roseburia
Species: Roseburia intestinalis
Subspecies: Roseburia intestinalis XB6B3
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MKIVVLAGGLSTERDVSFKTGDMVAKALRENGHQVILLDVFMGYSDKKEDLTGIFDRSEE
VSVKVSGIPETAPDLAKVKASRKDQSDNFFGPNVIELCQMSDIVFMALHGENGENGKIQA
AFDLFGIRYTGTGYLSSALAMDKEMSKKLFLSAGIPAPKGASMKKADCSDDITKLGIQFP
CVVKPCCGGSSIGVSIAHNAEEYKAALDEAFRWEENLIVEEYVKGREFSVGVIEGKALPI
IEIAPVQGFYDYKNKYKAGSAVETCPAELSEAVTEKMQHYAEQVAQVLGLDTYSRTDFLL
DENENIYCLEANTLPGMTPTSLLPQEAQVVGVNFNELCEKLIQISLDKYEK
Function This enzyme is involved with UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---L-lysine ligase (EC 6.3.2.7) or UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---2,6-diaminopimelate ligase (EC 6.3.2.13), UDP-N-acetylmuramate---L-alanine ligase (EC 6.3.2.8), UDP-N-acetylmuramoyl-L-alanine---D-glutamate ligase (EC 6.3.2.9) and UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase (EC 6.3.2.10) in the synthesis of a cell-wall peptide.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Vancomycin
 Drug Info Approved Methicillin-resistant staphylococcus infection ICD11: 1D01 [1]
References
1 vanG element insertions within a conserved chromosomal site conferring vancomycin resistance to Streptococcus agalactiae and Streptococcus anginosus. mBio. 2014 Jul 22;5(4):e01386-14.

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