Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1422)
DME Name Molybdopterin-dependent enzyme (molD), Escherichia coli
Synonyms Molybdopterin-dependent oxidoreductase; Oxidoreductase molD; molD
Gene Name molD
UniProt ID
A0A327UAE0_9ACTN
EC Number    EC: 1.1.1.40     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.40
Lineage    Species: Escherichia coli     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Escherichia
Species: Escherichia coli
Subspecies: Escherichia coli BW25113
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MNPPEEDPGTPEPRIGPVPEKKPAFRPYHHPAAGWGAAKSVTRFLTKERELIDGPRAIAK
MNHENGGFDCPGCAWPDDIKGLKLDICENGIKHVTWEMTRKRVGREFFAAHSVSELSGWS
DFRLEDQGRLTEPMVYDPESDHYEPISWKDAFELVGRTLRGLDSPHQASFYTSGRLGNEA
TFLYQLWARELGTNNLPDCSNMCHEASGRALQAALGTGKGTCDLKDWESADALFIMGVNA
ASNAPRMLTALAEAYRRGAQVVHVNPLVEAAATRTIIPHDIADMAMFKSTRTSTLNLQVR
IGGDMAFLRGVAKAVLKQAETDPKALDREFIDRYTDGFDAYRALCEATGWDEIERQSGLS
RDAVLAAARVYGEADRSIISWCLGVTQHDHGVDTIREIVNVLLLRGNLGREGAGPSPVRG
HSNVQGNRTCGINHRPPEEFLDRLADACGIEPPREHGLDTVGTIRAMHDGDVKVFVGMGG
NFALAAPDTPYTYEALRNCDLTVQVSTKLNRSHLVHGRAALILPCLGRTEKDEQRAGLQS
TSVEDSMSMVHLSVGMKRPASRHLLSEPAIIAGMARATLPGSSTPWEWYVEDYDRIRDSM
ARVVEGFEDCNRRVRLPLGFRIRQPARELVFMTESGRAEFSTAPLPDVVPEPGTLALGTM
RSHDQWNTTIYSDDDRYRGITNLRTLVFMNKDDMRERGVEEFGPVDITSTARDGSRRRVE
GYLAVPYDIPRGCAAGYMPEMNVLCALVDYSTQSDQPLMKHVKVTITPSG
Function This enzyme catalyzes the conversion of doxorubicin to 7-deoxydoxorubicinol and 7-deoxydoxorubicinolone via a reductive deglycosylation mechanism.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Doxorubicin
 Drug Info Approved Breast cancer ICD11: 2C60 [1]
References
1 Transformation of the anticancer drug doxorubicin in the human gut microbiome. ACS Infect Dis. 2018 Jan 12;4(1):68-76.

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