Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1432)
DME Name Unclear metabolic mechanism (DME-unclear), Hungatella hathewayi
Gene Name DME-unclear
Lineage    Species: Hungatella hathewayi     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Clostridiaceae
Genus: Hungatella
Species: Hungatella hathewayi
Subspecies: Hungatella hathewayi DSM 13479
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:        15 Drugs
Mycophenolate mofetil
 Drug Info Approved Crohn disease ICD11: DD70 [1]
Terbinafine hydrochloride
 Drug Info Approved Pityriasis versicolor ICD11: 1F2D [1]
Norethindrone acetate
 Drug Info Approved Menorrhagia ICD11: GA20 [1]
Danazol
 Drug Info Approved Endometriosis ICD11: GA10 [1]
Omeprazole
 Drug Info Approved Gastro-oesophageal reflux disease ICD11: DA22 [1]
Sulfasalazine
 Drug Info Approved Rheumatoid arthritis ICD11: FA20 [1]
Pantoprazole sodium
 Drug Info Approved Gastro-oesophageal reflux disease ICD11: DA22 [1]
Ranitidine
 Drug Info Approved Peptic ulcer ICD11: DA61 [1]
Bromocriptine mesylate
 Drug Info Approved Parkinsonism ICD11: 8A00 [1]
Entacapone
 Drug Info Approved Parkinsonism ICD11: 8A00 [1]
Megestrol acetate
 Drug Info Approved Breast cancer ICD11: 2C60 [1]
Melphalan
 Drug Info Approved Multiple myeloma ICD11: 2A83 [1]
Tinidazole
 Drug Info Approved Protozoan infection ICD11: 1F5Z [1]
Olmesartan medoxomil
 Drug Info Approved Essential hypertension ICD11: BA00 [1]
Risperidone
 Drug Info Approved Schizophrenia ICD11: 6A20 [1]
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          5 Drugs
Artemisinin
 Drug Info Phase 4 Malaria ICD11: 1F40 [1]
Phenazopyridine
 Drug Info Phase 4 Infectious cystitis ICD11: GC00 [1]
Trimebutine
 Drug Info Phase 4 Irritable bowel syndrome ICD11: DD91 [1]
Racecadotril
 Drug Info Phase 4 Irritable bowel syndrome ICD11: DD91 [1]
Bisacodyl
 Drug Info Phase 4 Irritable bowel syndrome ICD11: DD91 [1]
      Drugs in Phase 2 Clinical Trial Click to Show/Hide the Full List of Drugs:          2 Drugs
ENT-50146
 Drug Info Phase 2 Cocaine addiction ICD11: 6C45 [1]
TU-199
 Drug Info Phase 2 Gastro-oesophageal reflux disease ICD11: DA22 [1]
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
BRN-0498823
 Drug Info Phase 1 Essential hypertension ICD11: BA00 [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Diacetamate
 Drug Info Investigative Discovery agent ICD: N.A. [1]
References
1 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.

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