General Information of DME (ID: DME1458)
DME Name Unclear metabolic mechanism (DME-unclear), Ruminococcus gnavus
Gene Name DME-unclear
Lineage    Species: Ruminococcus gnavus     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Lachnospiraceae
Genus: Blautia
Species: Ruminococcus gnavus
Subspecies: Ruminococcus gnavus ATCC 29149
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:        15 Drugs
Tacrolimus
Drug Info Approved Ulcerative colitis ICD11: DD71 [1]
Terbinafine hydrochloride
Drug Info Approved Pityriasis versicolor ICD11: 1F2D [1]
Deoxycholic acid
Drug Info Approved Obesity ICD11: 5B81 [2]
Levonorgestrel
Drug Info Approved Menorrhagia ICD11: GA20 [1]
Norethindrone acetate
Drug Info Approved Menorrhagia ICD11: GA20 [1]
Fluoxetine hydrochloride
Drug Info Approved Depression ICD11: 6A71 [1]
Danazol
Drug Info Approved Endometriosis ICD11: GA10 [1]
Omeprazole
Drug Info Approved Gastro-oesophageal reflux disease ICD11: DA22 [1]
Sulfasalazine
Drug Info Approved Rheumatoid arthritis ICD11: FA20 [1]
Pantoprazole sodium
Drug Info Approved Gastro-oesophageal reflux disease ICD11: DA22 [1]
Bromocriptine mesylate
Drug Info Approved Parkinsonism ICD11: 8A00 [1]
Entacapone
Drug Info Approved Parkinsonism ICD11: 8A00 [1]
Melphalan
Drug Info Approved Multiple myeloma ICD11: 2A83 [1]
Tinidazole
Drug Info Approved Protozoan infection ICD11: 1F5Z [1]
Risperidone
Drug Info Approved Schizophrenia ICD11: 6A20 [1]
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          3 Drugs
Artemisinin
Drug Info Phase 4 Malaria ICD11: 1F40 [1]
Phenazopyridine
Drug Info Phase 4 Infectious cystitis ICD11: GC00 [1]
Bisacodyl
Drug Info Phase 4 Irritable bowel syndrome ICD11: DD91 [1]
      Drugs in Phase 2 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
TU-199
Drug Info Phase 2 Gastro-oesophageal reflux disease ICD11: DA22 [1]
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
BRN-0498823
Drug Info Phase 1 Essential hypertension ICD11: BA00 [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Diacetamate
Drug Info Investigative Discovery agent ICD: N.A. [1]
References
1 Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467.
2 A biosynthetic pathway for a prominent class of microbiota-derived bile acids. Nat Chem Biol. 2015 Sep;11(9):685-90.

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