Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1481)
DME Name Alpha-L-rhamnosidase (lrA), Bacteroides thetaiotaomicron
Synonyms Alpha-L-rhamnosidase T; Alpha-L-rhamnosidase N; Alpha-L-rhamnoside rhamnohydrolase; SAMN02910431_01901
Gene Name SAMN02910431_01901
UniProt ID
A0A1H8EBM0_9BACE
EC Number    EC: 3.2.1.40     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.40
Lineage    Species: Bacteroides thetaiotaomicron     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Bacteroidaceae
Genus: Bacteroides
Species: Bacteroides thetaiotaomicron
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MNLKLKFILVYLSLCASAYTIQAQNIQYDPLLDPAVEIPDTPVRNGNGEYIWYPGQLSAH
LQQKRLKESEKRCVNVGYPGKFYAPVYHASFCKEVNLPAETLMEWTSTGKVKVSVNGKEA
GNSDKSSLTLPKGKSTLLFKVETDNDLPAIKVSFNGEVSTDHWKASMDGTEWNIAETSPV
FGTAGRMPLDDPETEVTIHPVSILPIRNATVENQKIKIQKNGYILVDFFHIEVGKVSFTA
KGEGKLTAFVGESPEEALNENTKLFEQYPIESYSLTEGEQQIILPERAVRYLKIFSDKEC
EISDVKFKAKIWPVDFLMSFECNDERMNNIWNASVASLHTSTHGFYLDGIKRDYLPWSMD
AVLSTFAGDYLFGDEQVSRNSLSVAMLPLNPQKTDLGIPDYPLHALIGFNHYYQRYGDFN
TILSYRDRIEQLLKLYETLQDERGFISANVGVSWGFVPGWATRRGPDKKGTPTYAQIMLY
YNYKIGADFSEKWGDKKSAKYYRMKSEDLKKSIIKHFWNEEQGLFINGYTKDGKLDTVIS
HHAQYWAILADIFPKERYDHLFEVLPTIPYYHDYVSYEKGYEFLAYSKAGKVREMWNFLF
TVFGDWLAQGHTRFPENFSYKKSKDEQLIFYKRPYGLSLCHGANGVPGVVAVLNGIAGFS
QSPTQPNHYTIRPELMDLEWANIEFPVKEGKIKLKLSKEGKNQIEIPDGCKVDFINQNKV
KKTFTKKGSYSM
Function This enzyme utilizes an inverting mechanism of hydrolysis, releasing beta-L-rhamnose. Substrates include naringin, rutin, quercitrin, hesperidin, dioscin, terpenyl glycosides and many other natural glycosides containing terminal alpha-L-rhamnose.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 2 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
BRN-0075455
 Drug Info Phase 2/3 Diabetes mellitus ICD11: 5A10 [1]
References
1 Identification of rutin deglycosylated metabolites produced by human intestinal bacteria using UPLC-Q-TOF/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Jun 1;898:95-100.

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