Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1512)
DME Name L-Lactate dehydrogenase (ldh), Lactobacillus casei
Synonyms L-lactate ferricytochrome C oxidoreductase; Cytochrome b2 mitochondrial; L-LCR; L-LDH; ldh
Gene Name ldh
UniProt ID
LDH_LACCA
Gene ID
31583240
EC Number    EC: 1.1.1.27     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.27
Lineage    Species: Lactobacillus casei     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus casei
Subspecies: Lactobacillus casei ATCC 393
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MASITDKDHQKVILVGDGAVGSSYAYAMVLQGIAQEIGIVDIFKDKTKGDAIDLSNALPF
TSPKKIYSAEYSDAKDADLVVITAGAPQKPGETRLDLVNKNLKILKSIVDPIVDSGFNGI
FLVAANPVDILTYATWKLSGFPKNRVVGSGTSLDTARFRQSIAEMVNVDARSVHAYIMGE
HGDTEFPVWSHANIGGVTIAEWVKAHPEIKEDKLVKMFEDVRDAAYEIIKLKGATFYGIA
TALARISKAILNDENAVLPLSVYMDGQYGLNDIYIGTPAVINRNGIQNILEIPLTDHEEE
SMQKSASQLKKVLTDAFAKNDIETRQ
Structure
1LLC ; 2ZQY ; 2ZQZ ; 6J9S ; 6J9T ; 6J9U
Function This enzyme catalyzes the conversion of lactate to pyruvate, and it also oxidizes other (S)-2-hydroxymonocarboxylic acids.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
DB-053072
 Drug Info Phase 1 Prostate cancer ICD11: 2C82 [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          2 Drugs
Methylglyoxal
 Drug Info Investigative Alzheimer disease ICD11: 8A20 [2]
Glucose-bisphosphate
 Drug Info Investigative Discovery agent ICD: N.A. [1]
      Experimental Enzyme Kinetic Data of Drugs Click to Show/Hide the Full List of Drugs:          2 Drugs
DB-053072
 Drug Info Phase 1 Prostate cancer Km = 1000 microM [1]
Glucose-bisphosphate
 Drug Info Investigative Discovery agent Km = 10 microM [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR004257 Pyruvate L-lactate Unclear - Unclear Methylglyoxal [2]
References
1 Purification, properties and immunological relationship of L (+)-lactate dehydrogenase from Lactobacillus casei. Eur J Biochem. 1976 Aug 16;67(2):543-55.
2 Cells producing their own nemesis: understanding methylglyoxal metabolism

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