Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1513)
DME Name Maltose phosphorylase (malP), Lactobacillus brevis
Synonyms Glycoside hydrolase 65 protein; Glycoside hydrolase family 65; Glycoside hydrolase family 65 protein; Kojibiose phosphorylase; LbDm2_0970
Gene Name malP
UniProt ID
A0A0C1MAP6_LACBR
EC Number    EC: 2.4.1.8     (Click to Show/Hide the Complete EC Tree)
Transferase
Glycosyltransferases
Hexosyltransferase
EC: 2.4.1.8
Lineage    Species: Lactobacillus brevis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus brevis
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MKRIFEVQPWNVITHTFDPKDKRLQESMTSLGNGYMGMRGDFEEGYSGDSLQGIYLGGVW
YPDKTRVGWWKNGYPKYFGKVVNAVNFIKLPIEINGEPVDLAKDKISDFTLDLDMHQGVL
NRSFVVERGAVRVALNFQRFLSVAQPELSVQKVTVKNLSDAEVDVTLKPSIDADVMNEEA
NYDERFWDVLATDQQADRGSIVAKTTPNPFGTPRFTSGMEMRLVTDLKNVAITQPNEKEV
TTAYTGKLAPQASAELEKRVIVVTSRDYDTQESLTAAMHQLSDKVAQSSYEDLLNAHTAI
WAQRWEKSDVVIQGDDESQQGIRFNLFQLFSTYYGDDARLNIGPKGFTGEKYGGATYWDT
EAFAFPVYLGITDPKVTRNLLMYRYKQLDGAYINAQEQGLKGALFPMVTFDGIECHNEWE
ITFEEIHRNGDIAFAIYNYTRYTGDDSYVLHEGAKVLTEISRFWADRVHFSKRNNQYMIH
GVTGADEYENNVDNNWDTNMLAQWTLKYTLEILGKVDQDTAKQLDVSDEEKTKWQDIVDR
MYLPYDKDLNIFVQHDGFLDKDIEPVSSIPADQRPINQNWSWDKILRSPYIKQGDVLQGI
WDFIDDYTPEQKKANFDFYEPLTVHESSLSPAIHSVLAADLHYEDKAVELYSRTARLDLD
NYNNDTTDGLHITAMTGGWIAVVQGFAGMRVRDGQLHYAPFLPKTWTSYTFRQVFRDRLI
EVSVHADGPHFKLLSGEPLTIDVAGEKVELTQNVTA
Function This enzyme catalyzes the conversion of maltose to D-glucose and beta-D-glucose 1-phosphate.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Ortho-phosphate
 Drug Info Phase 4 Thyroid cancer ICD11: 2D10 [1]
References
1 Maltose phosphorylase from Lactobacillus brevis: purification, characterization, and application in a biosensor for ortho-phosphate. Enzyme Microb Technol. 1997 Nov 1;21(6):413-20.

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