Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1539)
DME Name Beta-lactamase (blaB), Prevotella pallens
Synonyms Penicillinase; Cephalosporinase; Beta-lactam; Beta-lactamase induction signal transducer AmpG; ampG; HMPREF9144_0774
Gene Name ampG
UniProt ID
F9DGI4_9BACT
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Prevotella pallens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Prevotellaceae
Genus: Prevotella
Species: Prevotella pallens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MQEPNIKKRVSPWAWVSTLYFAEGLPNAAVVLVSLVFYQEMGLSDAEATFYTSWFYLPWV
IKPLWSPFLDLIKTKRWWVLSMQMLLGAAFAGVAFTINTSFWLQGTICFFWLLAISSATH
DVGADGFYMLGLESHEQAFFVGIRSTFYRISMVVGKGGLVALAGLLQEYMKVQLSWSLVF
YGLSALFIGLSLYHKCILPKPITDVEHTQLSVSTLFKEFLDTFVSFFRKKEVFVAIAFML
LFRLPEALLNTVGPLFLRATSEKGGLALSLEAFGVVNGVVGVVGLLLGGILGGLVASKGG
LKKWLWPMTFAITLPNIAYVYLGYAMPSTLFAVGVAIFVENFGYGFGFSAYMLFMLYFSQ
GEHKTSHYALCTGFMALSMMLPGLFAGALAEAVGYSLFFVLVMVACIFPFMVASLLKIDP
KFGKKDI
Function This enzyme hydrolyzes beta-lactam.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Penicillin G
 Drug Info Approved Diphtheria ICD11: 1C17 [1]
References
1 Beta-lactamase production in Prevotella intermedia, Prevotella nigrescens, and Prevotella pallens genotypes and in vitro susceptibilities to selected antimicrobial agents. Antimicrob Agents Chemother. 1999 Oct;43(10):2383-8.

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