Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1542)
DME Name Sucrose-6-phosphate hydrolase scrB (ScrB), Anaerostipes caccae
Synonyms Sucrose-phosphate hydrolase B; Invertase B; Sucrase B; ANACAC_00495
Gene Name ScrB
UniProt ID
B0MAC0_ANACD
EC Number    EC: 3.2.1.26     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.26
Lineage    Species: Anaerostipes caccae     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Lachnospiraceae
Genus: Anaerostipes
Species: Anaerostipes caccae
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human oral cavity.
Sequence
MFKKYNKVLKEDYEKWYAEHESDREETAKDPMRLKFHLMPKTGWLNDPNGLCQFHGTYHI
YYQYTPFEPTGELKLWGHYTTKDFISYIDEGPVLFPDSEFDAHGVYSGSAFVKGDTIHYF
YTGNIKCFDRDDYDYINSGRGSNTIHVASKDGYHFSEKDLLMTTDDYPEDMSCHVRDPKI
IRRGDDYYMVQGARDIDSHGLILMFHSKDLSHWEYFDRIVPKEPFGYMWECPDLFELDGQ
MMLITCPQGVEPKGIDYQNVHQCTAVKMDYDFENKSYEICDNSEFQQLDRGFDFYAPQTF
EDEKGRRILIGWMGIPDADYTNPTVEHGWQHALTIPRELHIKDGRIIQRPIKEMEQMRKG
ELICTFSEQGRMESNLKLYEAEVRFRHCADMVLTLKEGVTLSYDSGLLTLDLGDFGEGRT
TRCAALDELKDLRIFADTTSLEIFVNGGEEVFTTRVYSSQGKLSIDGDCSGTMKIYCLRP
LEIGERE
Function This enzyme takes part in glucuronoside catabolic process. Substrates include sucrose.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          2 Drugs
Kestose
 Drug Info Preclinical Atopic dermatitis ICD11: EA80 [1]
Sucrose
 Drug Info Investigative Prematurity retinopathy ICD11: 9B71 [1]
References
1 Characterization of fructooligosaccharide-degrading enzymes in human commensal Bifidobacterium longum and Anaerostipes caccae. Biochem Biophys Res Commun. 2019 Oct 15;518(2):294-298.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.