| General Information of DME (ID: DME1551) |
| DME Name |
Cytochrome P450 125A1 (cyp125), Mycobacterium tuberculosis
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| Synonyms |
Cytochrome P450 family 125 subfamily A member 1; Cholest-4-en-3-one 26-monooxygenase 125A1; Cholest-4-en-3-one C26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming] 125A1; Cholesterol C26-monooxygenase 125A1; Cholesterol C26-monooxygenase [(25S)-3beta-hydroxycholest-5-en-26-oate forming] 125A1; MTCY03C7.11; Rv3545c; Steroid C26-monooxygenase 125A1; Steroid C27-monooxygenase 125A1; cyp125A1
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| Gene Name |
cyp125
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| UniProt ID |
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| Gene ID |
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| EC Number |
EC: 1.14.15.29 (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Iron-sulfur protein donor oxidoreductase
EC: 1.14.15.29
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| Lineage |
Species: Mycobacterium tuberculosis (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Corynebacteriales
Family: Mycobacteriaceae
Genus: Mycobacterium
Species: Mycobacterium tuberculosis
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Interactome(loading-time for this interactome depdends on the speed of web connection)
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Interactions between Xenobiotics and DME (XEOTIC)  Jump to Detailed Interactome Data  |
Interactions between Host Protein and DME (HOSPPI) Jump to Detailed Interactome Data |
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Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
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| Tissue Distribution |
Primarily distributed in human gut.
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| Sequence |
MSWNHQSVEIAVRRTTVPSPNLPPGFDFTDPAIYAERLPVAEFAELRSAAPIWWNGQDPG
KGGGFHDGGFWAITKLNDVKEISRHSDVFSSYENGVIPRFKNDIAREDIEVQRFVMLNMD
APHHTRLRKIISRGFTPRAVGRLHDELQERAQKIAAEAAAAGSGDFVEQVSCELPLQAIA
GLLGVPQEDRGKLFHWSNEMTGNEDPEYAHIDPKASSAELIGYAMKMAEEKAKNPADDIV
TQLIQADIDGEKLSDDEFGFFVVMLAVAGNETTRNSITQGMMAFAEHPDQWELYKKVRPE
TAADEIVRWATPVTAFQRTALRDYELSGVQIKKGQRVVMFYRSANFDEEVFQDPFTFNIL
RNPNPHVGFGGTGAHYCIGANLARMTINLIFNAVADHMPDLKPISAPERLRSGWLNGIKH
WQVDYTGRCPVAH
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| Structure |
2X5L
; 2X5W
; 2XC3
; 2XN8
; 3IVY
; 3IW0
; 3IW1
; 3IW2
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| Pathway |
Microbial metabolism in diverse environments (mtu01120 ) |
| Steroid degradation (mtu00984 ) |
| Function |
This enzyme is a P-450 heme-thiolate protein found in several bacterial pathogens, and it is involved in degradation of the host's cholesterol. The enzyme catalyses the hydroxylation of the C-26 carbon, followed by oxidation of the alcohol to the carboxylic acid via the aldehyde intermediate, initiating the degradation of the alkyl side-chain of cholesterol . The products are exclusively in the (25S) configuration. And it also accepts cholesterol as a substrate.
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