Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1558)
DME Name	Unclear metabolic mechanism (DME-unclear), Streptomyces griseus
Gene Name	DME-unclear
Lineage	Species: Streptomyces griseus (Click to Show/Hide the Complete Species Lineage) Kingdom: Bacteria Phylum: Actinobacteria Class: Actinobacteria Order: Streptomycetales Family: Streptomycetaceae Genus: Streptomyces Species: Streptomyces griseus Subspecies: Streptomyces griseus ATCC 13273
Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution	Primarily distributed in human blood.

Full List of Drug(s) Metabolized by This DME
Drugs Approved by FDA			Click to Show/Hide the Full List of Drugs: 1 Drugs
Colchicine	Drug Info	Approved	Uncontrolled gout	ICD11: FA25	[1], [2]

References
1	Microbial catalyzed regio-selective demethylation of colchicine by Streptomyces griseus ATCC 13273. Appl Biochem Biotechnol. 2017 Nov;183(3):1026-1034.
2	Resistance of alkaline phosphatase of human serum to the protease of Streptomyces griseus. Biochim Biophys Acta. 1968 Jun 4;159(2):405-7.

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