Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1561)
DME Name Beta-lactamase (blaB), Burkholderia pseudomallei
Synonyms Penicillinase; Cephalosporinase; Beta-lactam; blaOXA; DM992_27500
Gene Name blaOXA
UniProt ID
A0A2U9SV73_9BURK
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Burkholderia pseudomallei     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Betaproteobacteria
Order: Burkholderiales
Family: Burkholderiaceae
Genus: Burkholderia
Species: Burkholderia pseudomallei
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human oral cavity.
Sequence
MESRLNTWRRTLFVFATGLLAAASASARPVCTVVADAATGQTLVRQGDCATRVTPASTFK
VAISLMGFDAGFLKDEHTPTLDFHAGYPDWGGAPWREPTDPARWIKLSIFWYSEQVAQAL
GPARFQQYTNAFGYGNTDVTGKQGELSGVMGAWVNSSLRISPLEQVAFMRKILHRTLPVS
THAYDMTERITLIDAQPGGWTVHGKTGTGSPGLKYDAAHAYGWFVGWATKGPRTLVFANL
IQDDKRQTPNAGLRSRDTFLAALPALAEPARPQ
Function This enzyme hydrolyzes beta-lactam.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Ampicillin
 Drug Info Approved Endocarditis ICD11: 1B12 [1]
References
1 Beta-lactamase production and antimicrobial susceptibility of subgingival bacteria from refractory periodontitis. Oral Microbiol Immunol. 2004 Oct;19(5):303-8.

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