Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1563)
DME Name Beta-lactamase (blaB), Ralstonia pickettii
Synonyms Penicillinase; Cephalosporinase; Beta-lactam; bla OXA-60; blaOXA; blaOXA-60a; CJ026_005695
Gene Name bla
UniProt ID
Q6EZ46_RALPI
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Ralstonia pickettii     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Betaproteobacteria
Order: Burkholderiales
Family: Burkholderiaceae
Genus: Ralstonia
Species: Ralstonia pickettii
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human oral cavity.
Sequence
MLSRYSKTLAFAVVACTLAISTATAHAELVVRNDLKRVFDDAGVSGTFVLMDITADRTYV
VDPARAARSIHPASTFKIPNSLIAFDTGAVRDDQEVLPYGGKPQPYEQWEHDMALPEAIR
LSAVPIYQEVARRVGFERMQAYVDAFDYGNRQLGSAIDQFWLRGPLEISAFEEARFTSRM
ALKQLPVKPRTWDMVQRMLLIEQQGDAALYAKTGVATEYQPEIGWWAGWVERAGHVYAFA
LNIDMPREGDMAKRIPLGKQLMRALEVWPAP
Function This enzyme hydrolyzes beta-lactam.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Ampicillin
 Drug Info Approved Endocarditis ICD11: 1B12 [1]
References
1 Beta-lactamase production and antimicrobial susceptibility of subgingival bacteria from refractory periodontitis. Oral Microbiol Immunol. 2004 Oct;19(5):303-8.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.