Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1584)
DME Name Retro-nitroreductase (rNR), Enterobacter cloacae
Synonyms Retro-FMN reductase (NAD(P)H); Retro-FMN reductase NADPH; ECL_03157
Gene Name rNR
UniProt ID
A0A0H3CM55_ENTCC
Gene ID
9125636
EC Number    EC: 1.5.1.34     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-NH donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.5.1.34
Lineage    Species: Enterobacter cloacae     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Enterobacter
Species: Enterobacter cloacae
Interactome
(loading-time for this interactome depdends on the speed of web connection)
       Interactions between Xenobiotics and DME (XEOTIC)                      
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MDIISVALKRHSTKAFDPAKKLTADEAEKIKTLLQYSPSSTNSQPWHFIVASTEEGKARV
AKSAAGTYVFNERKMLDASHVVVFCAKTAMDDAWLERVVDQEEADGRFNTPEAKAANHKG
RTYFADMHRVDLKDDDQWMAKQVYLNVGNFLLGVAALGLDAVPIEGFDAAILDEEFGLKE
KGFTSLVVVPVGHHSVEDFNATLPKSRLPLSTIVTEC
Pathway Microbial metabolism in diverse environments (enc01120 )
Nitrotoluene degradation (enc00633 )
Function This enzyme uses NADH as source of reducing equivalents to reduce of a variety of nitroaromatic compounds.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
AI3-23606
 Drug Info Phase 1 Trypanosomiasis ICD11: 1F51 [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          2 Drugs
Nitroimidazole
 Drug Info Investigative Discovery agent ICD: N.A. [1]
Quinone
 Drug Info Investigative Prostate cancer ICD11: 2C82 [1]
References
1 Retro-nitroreductase, a putative evolutionary precursor to Enterobacter cloacae strain 96-3 nitroreductase. Antioxid Redox Signal. 2001 Oct;3(5):747-55.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.