Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1623)
DME Name VanB ligase (vanB), Desulfitobacterium hafniense
Synonyms Vancomycin B-type resistance protein VanB; D-alanylalanine synthetase VanB; D-alanine--D-alanine ligase VanB; D-Ala-D-Ala ligase VanB; vanB
Gene Name vanB
UniProt ID
Q58F99_ENTFC
EC Number    EC: 6.3.2.4     (Click to Show/Hide the Complete EC Tree)
Ligase
Carbon-nitrogen ligase
Peptide synthase
EC: 6.3.2.4
Lineage    Species: Desulfitobacterium hafniense     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Peptococcaceae
Genus: Desulfitobacterium
Species: Desulfitobacterium hafniense
Subspecies: Desulfitobacterium hafniense DCB-2
Subspecies: Desulfitobacterium hafniense DP7
Subspecies: Desulfitobacterium hafniense G2
Subspecies: Desulfitobacterium hafniense PCE-S
Subspecies: Desulfitobacterium hafniense PCP-1
Subspecies: Desulfitobacterium hafniense TCP-A
Subspecies: Desulfitobacterium hafniense TCE1
Subspecies: Desulfitobacterium hafniense Y51
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLCKKPCTEWE
ADSLPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKCGEDGAIQGLFVLSGIPYVG
CDIQSSAACMDKSLAYILTKNAGIAVPEFQMIDKGDKPEAGALTYPVFVKPARSGSSFGV
TKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIVGEVDQIRLSHGIF
RIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGLARVDLFLQEDGGI
VLNEVNTLPGFTSYSRYPRMMAAAGITLPALIDSLITLALKR
Function This enzyme produces the depsipeptide D-alanyl-(R)-lactate, which can be incorporated into the peptidoglycan pentapeptide instead of the usual D-alanyl-D-alanine dipeptide. The resulting peptidoglycan does not bind the glycopeptide antibiotics vancomycin and teicoplanin, conferring resistance on the bacteria.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Vancomycin
 Drug Info Approved Methicillin-resistant staphylococcus infection ICD11: 1D01 [1]
References
1 vanI: a novel D-Ala-D-Lac vancomycin resistance gene cluster found in Desulfitobacterium hafniense. Microb Biotechnol. 2014 Sep;7(5):456-66.

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