General Information of DME (ID: DME1688)
DME Name L-Lactate dehydrogenase (ldh), Lactobacillus delbrueckii
Synonyms L-lactate ferricytochrome C oxidoreductase; Cytochrome b2 mitochondrial; L-LCR; L-LDH; LBUL_0100
Gene Name ldh
UniProt ID
LDH_LACDB
EC Number    EC: 1.1.1.27     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.27
Lineage    Species: Lactobacillus delbrueckii     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus delbrueckii
Subspecies: Lactobacillus delbrueckii subsp. bulgaricus
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MSRKVLLVGDGAVGSNFANDLLQTTQVDELVICDLNKDRAAGDCLDLEDMTYFTGQTKLR
AGDYSDAADADVVVITAGVPRKPGESRLDLIKKNEAILRSIVDPVVASGFSGIFVVSANP
VDILTTLTQKLSGFPKKRVIGTGTSLDSARLRVELAKRLQVPIESVNAWVLGEHGDSSFE
NFSSAVVNGKPLLDYPGMTEAALDEIEAHVREKGSEIIVKKGATYYGVAMMLAKIVTAIL
ENNDLALPLSAPLHGEYGIKDEIYLGTLAIINGQGISHVLELPLNDSELAKMRASAATIK
ATLDSLG
Pathway Biosynthesis of secondary metabolites (lbu01110 )
Cysteine and methionine metabolism (lbu00270 )
Glycolysis / Gluconeogenesis (lbu00010 )
Metabolic pathways (lbu01100 )
Microbial metabolism in diverse environments (lbu01120 )
Propanoate metabolism (lbu00640 )
Pyruvate metabolism (lbu00620 )
Function This enzyme catalyzes the conversion of lactate to pyruvate, and it also oxidizes other (S)-2-hydroxymonocarboxylic acids.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
DB-053072
Drug Info Phase 1 Prostate cancer ICD11: 2C82 [1]
References
1 Positive selection on D-lactate dehydrogenases of Lactobacillus delbrueckii subspecies bulgaricus. IET Syst Biol. 2015 Aug;9(4):172-9.

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