Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1694)
DME Name Xylose isomerase (xylA), Alistipes indistinctus
Synonyms Xylose isomerase xylA; Isomerase xylA; Enzyme xylA; xylA; DEB64_01060
Gene Name xylA
UniProt ID
A0A358M0K8_9BACT
EC Number    EC: 5.3.1.5     (Click to Show/Hide the Complete EC Tree)
Isomerase
Intramolecular oxidoreductase
Aldose/ketose isomerase
EC: 5.3.1.5
Lineage    Species: Alistipes indistinctus     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Rikenellaceae
Genus: Alistipes
Species: Alistipes indistinctus
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MAKQYFPTVGKIAFEGTSSKNPMAFRYYEPERVVKGRKMKDWLRFSMAWWHTLCAEGADQ
FGGGTKQFAWNEAACPIERAKAKMDAGFEFMQKMGIEYYCFHDVDLVDEDPDPVKYEQNL
REIVAYAKQKQAETGIKLLWGTANVFGNARYMNGASTNPDFDTAARAMLQIKNAIDATIE
LGGENYVFWGGREGYMSLLNTDMKREKEHMATMLTMARDYARSKGFKGNFLIEPKPMEPM
KHQYDVDTETVIGFLRAHGLDKDFKVNIEVNHATLAGHTFEHELQCAVDAGMLGSIDANR
GDYQNGWDTDQFPIDLYEMVQAMMVIVRGGGLQGGGTNFDAKTRRNSTDPEDLFIAHIAA
MDVMARALLIAADLLDNSPYQKMLAERYASYDKGEGKAFEEGKLTLEQVADYARTHEPVQ
HSGKQELYEAILNMYM
Function This enzyme catalyzes the interconversion of aldose and ketose sugars with broad substrate specificity. It binds the closed form of its sugar substrate (in the case of glucose, only the alpha anomer) and catalyses ring opening to generate a form of open-chain conformation that is coordinated to one of the metal sites.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Xylose
 Drug Info Approved Malabsorption syndrome ICD11: DA96 [1]
References
1 Bacterial xylose isomerases from the mammal gut Bacteroidetes cluster function in Saccharomyces cerevisiae for effective xylose fermentation. Microb Cell Fact. 2015 May 17;14:70.

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