Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1721)
DME Name Glycosyl hydrolase (glyH), Clostridium butyricum
Synonyms Glycosidase; Glycoside hydrolase; Furcatin hydrolase; Isoflavonoid 7-O-apiosylglucosidase; NCTC7914_04276; bglB
Gene Name bglB
UniProt ID
A0A379KQ43_PSEPU
EC Number    EC: 3.2.1.18     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.18
Lineage    Species: Clostridium butyricum     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Clostridiaceae
Genus: Clostridium
Species: Clostridium butyricum
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MKHFKQAVSLMALGVMQASGALAAGPATGNEVEARVSSILDNMNQAEKINFTRVNDGHMI
PSLLKWGIQGTVAYDSSMGVHVNNATFGAQYPSQSALAATWSINRAKEFGLAIAYETRIS
GGQQMLSPGVNLYRTPYNGRSAEYVSGEDPFLGAVLAPAIVNGIQAQGIQASGKHYLANE
QEANRQAVNVVADERTLRELYLPGFESMVKNANVASIMCGFNKVNGDYACENHHLITEVL
KGEWGYQGTVISDFNAIHDPFKGAWAGTDLDMPSGLQFTEANLLPYLWSGQLTQNVIDDK
VKRNLRAVVSYDFQENLNTAKTLEHTEYGQRASLNAAREGIVLLRNADTAAGKPLLPLAR
TARIAVIGDWANQAPASPFGTANSPPNSYVTELSGLQQLASNSANVTYLSALSLNPKAAV
WYQPTSSGSGVSNAGVKAEYFSNTSLSGDPVLTRIEPGVNLNWTTSTNETSTGTTAVSGF
SPTAGAFSARFSATIKPTVSGAHVFKVRADGPYKLWVDGKLVVQSDGVPYSSDVVNALTT
SGKSAALVAGKSYNVKLEYRRVQGNFTPALGGLAGVQMSWASLRPPKDIASYDAVVIAAG
TNYENEGEGSDHGYALPDQQAELIKFVTKANPNTIVVTHGGGVADMQPWAKKVGAALHAW
FPGQQGGQALAEILYGKVNPSGKLPVTIDKKIEDNPSYASYPDPAAYRGDNPLTEIDYSE
GLYMGYRGYDKKHAKPLYPFGFGLSYTTFGYSDLKLSTNVMTPGNTVNATFTLTNTGDKA
GFEVAQLYIQPIAPQVDRPKKELKGFTKVYLEPGQSKTVSLPIDSRSLAYFVQNTDSWDV
DAGKFKVWVGPDSENLTLQRTLVTLMPQHLTTRDSNPLPAPLQAAVQVSDSQAY
Function This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosides.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
LS-69767
 Drug Info Phase 1 Chronic myelogenous leukaemia ICD11: 2A20 [1]
References
1 In vitro fermentation of fructooligosaccharides with human gut bacteria. Food Funct. 2015 Mar;6(3):947-54.

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