Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1746)
DME Name Cytochrome P450 101B1 (cyp101), Novosphingobium aromaticivorans
Synonyms Cytochrome P450 family 101 subfamily B member 1; Cytochrome P450-cam B1, Cytochrome P450cam B1; P450 101B1; cyp101B1
Gene Name cyp101
UniProt ID
Q2G637_NOVAD
EC Number    EC: 1.14.15.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Iron-sulfur protein donor oxidoreductase
EC: 1.14.15.1
Lineage    Species: Novosphingobium aromaticivorans     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Alphaproteobacteria
Order: Sphingomonadales
Family: Sphingomonadaceae
Genus: Novosphingobium
Species: Novosphingobium aromaticivorans
Subspecies: Novosphingobium aromaticivorans DSM 12444
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MIPAHVPADRVVDFDIFNPPGVEQDYFAAWKTLLDGPGLVWSTANGGHWIAARGDVVREL
WGDAERLSSQCLAVTPGLGKVMQFIPLQQDGAEHKAFRTPVMKGLASRFVVALEPKVQAV
ARKLMESLRPRGSCDFVSDFAEILPLNIFLTLIDVPLEDRPRLRQLGVQLTRPDGSMTVE
QLKQAADDYLWPFIEKRMAQPGDDLFSRILSEPVGGRPWTVDEARRMCRNLLFGGLDTVA
AMIGMVALHLARHPEDQRLLRERPDLIPAAADELMRRYPTVAVSRNAVADVDADGVTIRK
GDLVYLPSVLHNLDPASFEAPEEVRFDRGLAPIRHTTMGVGAHRCVGAGLARMEVIVFLR
EWLGGMPEFALAPDKAVTMKGGNVGACTALPLVWRA
Structure
3OFT ; 3OFU
Function This enzyme is a P-450 heme-thiolate protein, and it also acts on (-)-camphor and 1,2-campholide, forming 5-exo-hydroxy-1,2-campholide.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Beta-ionone
 Drug Info Investigative Breast cancer ICD11: 2C60 [1], [2]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR007557 Beta-ionone 3-hydroxy--ionone Unclear - Unclear Beta-ionone [3]
References
1 Patients with primary biliary cirrhosis react against a ubiquitous xenobiotic-metabolizing bacterium. Hepatology. 2003 Nov;38(5):1250-7.
2 A cytochrome P450 class I electron transfer system from Novosphingobium aromaticivorans. Appl Microbiol Biotechnol. 2010 Mar;86(1):163-75.
3 In Vitro Regio- and Stereoselective Oxidation of -Ionone by Human Liver Microsomes

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