Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1758)
DME Name	Unclear metabolic mechanism (DME-unclear), Paenibacillus aestuarii
Gene Name	DME-unclear
Lineage	Species: Paenibacillus aestuarii (Click to Show/Hide the Complete Species Lineage) Kingdom: Bacteria Phylum: Firmicutes Class: Bacilli Order: Bacillales Family: Paenibacillaceae Genus: Paenibacillus Species: Paenibacillus aestuarii
Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution	Primarily distributed in human gut.

Full List of Drug(s) Metabolized by This DME
Preclinical/investigative Agents			Click to Show/Hide the Full List of Drugs: 2 Drugs
Stigmasterol	Drug Info	Investigative	Allergy	ICD11: 4A80	[1]
Phytosterols	Drug Info	Investigative	Hypertriglyceridaemia	ICD11: 5C80	[1], [2]

References
1	Degradation of phytosterols in tobacco waste extract by a novel Paenibacillus sp. Biotechnol Appl Biochem. 2017 Nov;64(6):843-850.
2	Dysbiotic gut microbes may contribute to hypertension by limiting vitamin D production. Clin Cardiol. 2019 Aug;42(8):710-719.

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