Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1869)
DME Name Glycerol/diol dehydratase (dhaB), Flavonifractor plautii
Synonyms Glycerol dehydratase; Propanediol dehydratase pduC; A4U99_10800; ERS852504_00022; dhaB; pduC
Gene Name dhaB
UniProt ID
A0A174IA87_FLAPL
Gene ID
33071355
EC Number    EC: 4.2.1.30     (Click to Show/Hide the Complete EC Tree)
Lyases
Carbon-oxygen lyase
Hydro-lyase
EC: 4.2.1.30
Lineage    Species: Flavonifractor plautii     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Ruminococcaceae
Genus: Flavonifractor
Species: Flavonifractor plautii
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MKSKRFEVLAARPVNQDGYVQEWPEVGLIAMNSPFDPKPSIKIENGVITEMDGKCRADFD
MLDTFIADHAIRLGNAEKAMAMDSLEIARKIVDINVSREEILDITLSLTPAKLTEVVGKL
NIVEIMMGMTKMRARMMPANQCHVTNVRDNPVQIAADAAEAGVRGFAEMETTVAVARYAP
FNAMALFVGAQVGRPGVMTQCALEEATELQLGMRGFTTYAETISVYGTEPVFMDGDDTPY
SKAFLASCYASRGLKMRFTSGTGSEVQMGYAEGKSMLYLEARCLAVTKGAGVQGTQNGSV
SCIGVPAGVPGGIRAVAAENLIAMLLDLESTTSNDQTFTHSDLRRVARTVPQLFSGTDYI
CSGYSATPNYDNMFAGSNWDAEDYDDWTIIQRDMKIDGGLQPVREEDVLKARNKAARALQ
GMFRELGLPEITDAEVEAATYANGSNDMPERNVNEDLKAIEDMMARKVTGVDFVKALDRA
GFPDVAHNIYNMLRQKVAGDYLHTASIFDEQFHVLSAVNVPNEYHGPMTGYQISEERWNQ
LKNIPNAIRPEDI
Function This enzyme has two forms. One form requires a cobamide coenzyme, while the other is a glycyl radical enzyme.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
PhIP
 Drug Info Investigative Discovery agent ICD: N.A. [1]
References
1 Gut microbial beta-glucuronidase and glycerol/diol dehydratase activity contribute to dietary heterocyclic amine biotransformation. BMC Microbiol. 2019 May 16;19(1):99.

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