Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1871)
DME Name	Unclear metabolic mechanism (DME-unclear), Fusarium proliferatum
Gene Name	DME-unclear
Lineage	Species: Fusarium proliferatum (Click to Show/Hide the Complete Species Lineage) Kingdom: Fungi Phylum: Ascomycota Class: Sordariomycetes Order: Hypocreales Family: Nectriaceae Genus: Fusarium Species: Fusarium proliferatum Subspecies: Fusarium proliferatum F-0029-1
Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution	Primarily distributed in human skin.

Full List of Drug(s) Metabolized by This DME
Preclinical/investigative Agents			Click to Show/Hide the Full List of Drugs: 4 Drugs
Hydroxymanzamine A	Drug Info	Investigative	Ovarian cancer	ICD11: 2C73	[1]
Manzamine A	Drug Info	Investigative	Pancreatic cancer	ICD11: 2C10	[1]
Manzamine F	Drug Info	Investigative	Ovarian cancer	ICD11: 2C73	[1]
Ircinal A	Drug Info	Investigative	Alzheimer disease	ICD11: 8A20	[1]

References
1	Metabolism and resistance of Fusarium spp. to the manzamine alkaloids via a putative retro pictet-spengler reaction and utility of the rational design of antimalarial and antifungal agents. Mar Biotechnol (NY). 2014 Aug;16(4):412-22.

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