Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1921)
DME Name Beta-lactamase (blaB), Prevotella copri
Synonyms Penicillinase; Cephalosporinase; Beta-lactam; C7120_10955
Gene Name C7120_10955
UniProt ID
A0A2T4TNV5_9BACT
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Prevotella copri     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Prevotellaceae
Genus: Prevotella
Species: Prevotella copri
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human oral cavity.
Sequence
MKLKRLVFLIPIWLIALCSFGQAGHVSARLTLDGKMQALAERLLEGKQGSIVAIEPSTGE
VKCLVSKSFLSDTINRAIGQAYSPGSTFKVAQALALVSEGIVNKDSKFTCSEGFWKNNMH
IGCHKHSSPQDLIGAIAHSCNSWFCKAFMNMIRDRVKYKNKLEAINKWKEYMSSLGLGRP
LGIDMEGETDGEMPDSEMLERLYSGRWNEATIMWVGMGQGEVLATPLQLCNLAAIIANKG
YYYIPHIHKDVDTTYTTRRLSTASPEAFELIRKGMRKAVTTGTATAIQHPDWQICGKTGT
AENPGEDHSVFIGYAPMNNPKIAVSVYVENAGFGADLAAPLAQLMIEQYLTGKLSERSER
KARQWYDFLVVPHDPTEVTEKETPTKIPMPTQPASPSTSPKGKS
Function This enzyme hydrolyzes beta-lactam.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Amoxicillin
 Drug Info Approved Acute otitis media ICD11: AB00 [1]
References
1 High prevalence of cfxA beta-lactamase in aminopenicillin-resistant Prevotella strains isolated from periodontal pockets. Oral Microbiol Immunol. 2002 Apr;17(2):85-8.

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