Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1929)
DME Name Alpha-L-rhamnosidase (lrA), Lactobacillus rhamnosus
Synonyms Alpha-L-rhamnosidase T; Alpha-L-rhamnosidase N; Alpha-L-rhamnoside rhamnohydrolase; PY91_09320
Gene Name lrA
UniProt ID
A0A179YH30_LACRH
EC Number    EC: 3.2.1.40     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.40
Lineage    Species: Lactobacillus rhamnosus     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus rhamnosus
Subspecies: Lactobacillus rhamnosus NCTC 10302
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MPNITPSLLAPDHLRVNLQHFAYNIQAQPHFSWWNHSNRTGASQSAYQLTVFQRLQDRQN
HNYLYDSGWVTSSNNTAVTAAKLSDQLVPGQLYYWQVRIKDNAGSISDFSQPAKLICADP
SLPVKHGIWRQPQPKTAQELAHIGQVVFLRSPQLKINLSEVDTAVIVAVARGNEPVFAQS
FDLYLNGHCLGVGSARQQEHDHGTEKTAIYYNVYEATDFLQDGANTVAALATASSDRQAF
WCQLILYKHDGTKEVATTTDNTWRALDGSSAFGDYGVKIRTQYFGMVSENIDMRYYPQNW
TDSAFDDHDWPLAWQNPYQLIADNEVLVPFRSENTERVEVHDRNKRVVTFSDQNYLLDLG
KEIIGGLKVNLFSAFDQRVTVMMGEQLNDDGHVRHEMACGPDYIENWTLVKGQNQFTTLQ
MKNFRYVELVGFEGDLPLDAINGWAMQQAFPDNESQFDSDSELLNREYELSKYTIKATNQ
DVFVDSQARERRPYEGDLLVNANTSYSVSSNYSLARHSLDYLIDNPTWPEDYKLFAIEMA
WLDYLYTGDDDLLQTRYTDLQYKLNRGKSAESFDGASQSFTGSLKNSQGVDNFDAAVGLV
TNDGLVDWPISERDGFVEGTYNTPFNAIFHGAYATMAKIARVLHHPDDADRYQKRAEIIK
TNLIDKLYDPQTGRFFDSLNADLSVNRHTSHHASAYALCYGVYTDQNMADRLSHFVANDG
HFVGSIYFIYFMLKGLFEAGHAADAITLLTDPDNHKDHKSFAAILDSLKATIAPEAWSNA
YKPNLTLSHPWGATPGLTIVQGVFGIVPLAPGFATFRVKVRPGNLKHLDLTTPSVKGLIT
LHYRHEPTHQTLDVTVPMNTTAKVELPDDAQAIVVHDQYGKDWTASIEHDHDTLTIPMGR
YQIQYQA
Function This enzyme utilizes an inverting mechanism of hydrolysis, releasing beta-L-rhamnose. Substrates include naringin, rutin, quercitrin, hesperidin, dioscin, terpenyl glycosides and many other natural glycosides containing terminal alpha-L-rhamnose.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
VS-12343
 Drug Info Investigative Sickle-cell anaemia ICD11: 3A51 [1]
References
1 Catabolism of citrus flavanones by the probiotics Bifidobacterium longum and Lactobacillus rhamnosus. Eur J Nutr. 2018 Feb;57(1):231-242.

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