Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1939)
DME Name Beta-fructofuranosidase (BFRU), Roseburia inulinivorans
Synonyms Sucrose-6-phosphate hydrolase; Invertase; sacA; ERS852392_01502; ERS852444_00118
Gene Name sacA
UniProt ID
A0A173R035_9FIRM
EC Number    EC: 3.2.1.26     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.26
Lineage    Species: Roseburia inulinivorans     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Lachnospiraceae
Genus: Roseburia
Species: Roseburia inulinivorans
Subspecies: Roseburia inulinivorans DSM 16841
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MSNMLEKARKYETEKIAATDPQTKPLFHVSAPTGWINDPNGFSFYDGQIHLFYQYHPYNR
EWGPMHWGHSVTCDMIHWEQLPAALAPDEEYDKAGCFSGSAIEADGKHVLVYTGVTRIKQ
PDGSEQDRQNQCIAFGDGKDYQKYDKNPVMTGEMLPEGCNRVDFRDPKIWKENDTYYMIV
GNKNENQIGQVVLCSSKNLTDWKFETILASNESGKIGTMWECPDFFQLGSKRVLICSPQD
MKAQKYEFHNGHNSVYFLGDYDEKTHTFVKELPHALDYGMDFYAPQTTELPDGRRIMIAW
MKSWDACVIPNSQDWQGMMTLPRELELKDGKIWQTPVREIEKYHKNPCRYDHAEINQETT
LCGIEGRTIDLTVLLEEDEFQTFSMKLAANKEYETSFTYHKAENMLEIDRTYCGVTKDVV
CVRKLKISNPEGLKKMRFILDRQSIELFLNDGEQVATTAICTPLEAQEIHFYSDKKIHIN
VEKYDIMSASEKNAFMHSANDEIIE
Function This enzyme takes part in glucuronoside catabolic process. Substrates include sucrose.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Inulin
 Drug Info Approved Acute kidney failure ICD11: GB60 [1]
References
1 Substrate-driven gene expression in Roseburia inulinivorans: importance of inducible enzymes in the utilization of inulin and starch. Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4672-9.

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