Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME2023)
DME Name Beta-lactamase (blaB), Chryseobacterium oranimense
Synonyms Penicillinase; Cephalosporinase; Beta-lactam; SAMN05421866_1863
Gene Name blaB
UniProt ID
A0A1M5PLB6_9FLAO
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Chryseobacterium oranimense     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Flavobacteriia
Order: Flavobacteriales
Family: Flavobacteriaceae
Genus: Chryseobacterium
Species: Chryseobacterium oranimense
Subspecies: Chryseobacterium oranimense G311
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MNTRYLKIFSALVVIAIIFVARLSYLQLFTDRYALNAANTSIKIEYVIPQRGVVFDRNGK
ILVGNQPAYEISFTQALMKPDFDTIGFCNLMQISKSDFIKRIEIIKKEKYYSKLTPMTFI
KDLSREDIARVQEIIFKYPAFSIVSRPQRQYEVATSGNLLGYTSEVNEREIKKDSTYYLP
GDFIGKTGVEKSYEKDLRGIKGMKYIQKDIKLRNIGSYKNGSLDKDVVTGKDITLTIDYD
LQRIAEEMLVNKHGAIVAIDPNNGEILTLATGPDIDPNLFTGPNKSKNLYALSKDTLYEN
KPTFDRSVQAAYPPGSTFKLLTALAGMQMGVMDENTVFPCGGGFFYKGLRIKGHGGADPL
IPAIQVSSNCYFSHAFIAIMNKYPGDPSRGVNEWKKIMSSFGVGEYLNNDIAVGSPGRIP
TGEFYEKRSGKKNWSSDYTMNGSIFNGMGQGDVLVTPLQLANYVAAIANKGWFYTPHIVK
SIDGKPNPDPRFKTKHKTLVDPKHFEPVLKGMEAVVLRGTARSLKSSDFTQLAKTGTAQV
PQGKDNSIFVLIAPADKPRIVVAAVMEHAGFGATWAGPACTVIAEKYITGDLKRENLYKK
MTGASFMPEYKRQWIADLKRKGLYKDPTADSLKLKRKQDSLNFIKEQKAKLQKKIEEETK
NNTKKIKK
Function This enzyme hydrolyzes beta-lactam.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Imipenem
 Drug Info Phase 4 Acute pancreatitis ICD11: DC31 [1]
References
1 Whole-genome sequence of Chryseobacterium oranimense, a colistin-resistant bacterium isolated from a cystic fibrosis patient in France. Antimicrob Agents Chemother. 2015 Mar;59(3):1696-706.

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