Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME2046)
DME Name Beta-lactamase (blaB), Chryseobacterium gleum
Synonyms Penicillinase; Cephalosporinase; Beta-lactam; ftsI; NCTC12078_02492
Gene Name ftsI
UniProt ID
A0A4U8WDG3_9FLAO
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Chryseobacterium gleum     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Flavobacteriia
Order: Flavobacteriales
Family: Flavobacteriaceae
Genus: Chryseobacterium
Species: Chryseobacterium gleum
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MNPRHLKILSILIIIAVIFIARLSYLQLFTDRYALNAANTSIKTEYVIPQRGVIFDRNGK
ILVGNQPAYEISFTQALMKPDFDTAAFCNLMKITEKDFINRINKIKTEKYYSKLTPMTFL
KDLSREDIARVQEIIFKYPAFSIVQRPQRQYEVSTSGNLLGYTSEVNDREIRKDSTYYLP
GDLIGKAGVEKSYEKELRGIKGIKYIQKDIKLRSVGPYKNGTLDRDVVTGKDITLTIDYD
LQRMAEEMLVNKHGAIVALDPNNGEVLVAATGPDIDPNLFTGPNKSKNLYALSKDTIYEN
KPTFDRSLQAAYPPGSTFKLLTALAAMQMGLMDEKTIFPCGGGFYYKGKRIKGHGGADPL
IPSIQVSSNCFFTYAFIKIIKKYPGNPSRGVDEWKKIMSSFGVGEFLNNDFAVGAKGRIP
SGDFYERRFKAIMKASGSKRQDFKDWDEMSTGAIYNGMGQGDVLVTPIQLANYVAAIANK
GWYYTPHIVKSIDGKPNPDPRFKKKHQTLVDKKHFDPVLKGMEAVVLAGTARGLKSNDFT
QLAKTGTAQVPQGKDNSIFVLIAPADKPKIVVVAVMEHAGFGATWAGPASTVIAEKYITG
DLKREHLYKKMVTSSFMPEYKRQWIADLKRKGLYKEPKPDSLKLKKIQDSLNQAKKKKEA
LQKKLQLESSKTKKQ
Function This enzyme hydrolyzes beta-lactam.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Penicillin G
 Drug Info Approved Diphtheria ICD11: 1C17 [1]
References
1 Genetic and biochemical characterization of CGB-1, an Ambler class B carbapenem-hydrolyzing beta-lactamase from Chryseobacterium gleum. Antimicrob Agents Chemother. 2002 Sep;46(9):2791-6.

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