Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME2047)
DME Name	Unclear metabolic mechanism (DME-unclear), Enterococcus casseliflavus
Gene Name	DME-unclear
Lineage	Species: Enterococcus casseliflavus (Click to Show/Hide the Complete Species Lineage) Kingdom: Bacteria Phylum: Firmicutes Class: Bacilli Order: Lactobacillales Family: Enterococcaceae Genus: Enterococcus Species: Enterococcus casseliflavus Subspecies: Enterococcus casseliflavus CP1
Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution	Primarily distributed in human gut.

Full List of Drug(s) Metabolized by This DME
Drugs in Phase 2 Clinical Trial			Click to Show/Hide the Full List of Drugs: 2 Drugs
AS-35335	Drug Info	Phase 2/3	Venous thromboembolism	ICD11: BD72	[1]
BRN-0075455	Drug Info	Phase 2/3	Diabetes mellitus	ICD11: 5A10	[1]
Preclinical/investigative Agents			Click to Show/Hide the Full List of Drugs: 3 Drugs
Glucotropaeolin	Drug Info	Investigative	Infectious cystitis	ICD11: GC00	[2]
Sinigrin	Drug Info	Investigative	Hepatocellular carcinoma	ICD11: 2C12	[2]
Gluconasturtiin	Drug Info	Investigative	Prostate cancer	ICD11: 2C82	[2]

References
1	Degradation of quercetin-3-glucoside in gnotobiotic rats associated with human intestinal bacteria. J Appl Microbiol. 2000 Dec;89(6):1027-37.
2	Glucosinolate and desulfo-glucosinolate metabolism by a selection of human gut bacteria. Curr Microbiol. 2016 Sep;73(3):442-451.

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