General Information of DME (ID: DME2060)
DME Name Beta-glucosidase (bglA), Enterococcus faecium
Synonyms Periplasmic beta-glucosidase; Glucan endo-1 3-beta-D-glucosidase; Beta-D-glucosidase; HMPREF0351_10377; bglH
Gene Name bglH
UniProt ID
Q3Y0M8_ENTFD
Gene ID
12999036
EC Number    EC: 3.2.1.21     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.21
Lineage    Species: Enterococcus faecium     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Enterococcaceae
Genus: Enterococcus
Species: Enterococcus faecium
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MDQEIFPENFLWGGAVAANQCEGAWLEDGKLPNVTDTLIGIMNQHPSIQWNEEKKIWEIA
LDESLHYLSHEAIDFYHRFEEDIRLLKELGLKAFRTSISWARIFPRGDEQKPNEAGLVFY
DRLINTLNRYDIEPVITLSHYETPLALVGEYGGWQNRKLIDFFEFYAQTVFERYQGKVKY
WMTFNEINNAFRMPYAAAGLVTFPARDKLEPIATLTKKVIYQACHHMFLANARATQLLKK
IDPNAKMGIMCSFSALATYAYDCDPENVFGSLQFKRNSWFFSDVMCRGHYPAYIYRTWKE
EDCAPVMLDGDEQCLQANTADYIAFSYYRSAVYKKEAEMRVDTGGANGFDNPFLKEKSPE
PWSWPIDPLGFRYVMNELTDRYELPLFIVENGIGLDEAPDELNRIHDPKRCEYLKIHLQE
IAEAIKDGCQIIGYLWWGPIDIVSAGTGEMRKRYGFIYVDRQNDGSGSFRRLKKDSFEYY
KQIIQSNGKNLEYRSFFK
Pathway Glycolysis / Gluconeogenesis (efu00010 )
Starch and sucrose metabolism (efu00500 )
Function This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosides.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Lactulose
Drug Info Approved Hepatic encephalopathy ICD11: DB99 [1]
References
1 In vitro fermentation of lactulose by human gut bacteria. J Agric Food Chem. 2014 Nov 12;62(45):10970-7.

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