Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME2077)
DME Name Alpha-galactosidase (melA), Lactobacillus buchneri
Synonyms Alpha-D-galactoside galactohydrolase; 1,6-alpha-D-galactoside galactohydrolase; Galactosidase alpha; Ag-I; Ag-II; Aga-F78; Aga-Y; AgaA; agaAJB13; AgaB; AgaI; FIU77_02220
Gene Name melA
UniProt ID
A0A5P0VEV3_LACBU
EC Number    EC: 3.2.1.22     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.22
Lineage    Species: Lactobacillus buchneri     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus buchneri
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MAIRIEDQNLLFHLQTDHTSYIFHMMENGELGQIYYGKRVHSKPSYDNLVTREWHNAAAV
WRLDHKDVQPQVLKQEYASLGKGDFRYPAYQVAQANGSRITEFKYESYELVDGKQRLAGL
PSAFDDTDDDAQTLTIALRDKLLGLVMHLNYTIFPHQDVIVRSAEFQNQGNEKLRLNSAA
SAQLDLPDADYDFIQFSGAWARERHMIRTHLRSGVQSVGSLRGTSSHQQNPFVMLARPNT
DDAQGSVFGFNLIYSGNFSDQVQVDQYDASRVLVGINPEEFAWNLKPGDKFQTPEAVLSY
TDAGMNQLSQQMGAFYQDHLVNPRFAHEQRPTLINNWEATFMDFDEDKLLSFATTAKKLG
LEMFVLDDGWFGHRNNDDSSLGDWFVNEPKFPSGFGTFTQKIHDLGLKFGLWFEPEMISI
DSELYKQHPDWLINAPGRHASPERQQFVLDMTRSEVVDYLFDAMSKIIEMTKLDYIKWDM
NRNITETYSSQLSADDQLEVPHRYILGVYQLYDRLVKAYPDVLFESCSSGGGRFDLGMMY
YAPQAWTSDDTDAVERMLIQFGTSYGYPQTMMGAHVSAVPNDQVGRITSLKTRANVAYFG
DFGYELDITKMSPEEQQQVKEQTAFYKEHRQLFQFGKFYRIDNPFANGGNVMSWEVVSDD
QKHAIAARYQILNRPNTGYIRLYLKGLDPDTKYTVNGGSEQFYGDELMNAGLFVSDILHE
THGTDQSADFNSKLFVIDAVK
Function This enzyme hydrolyzes alpha-D-fucosides.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Melibiose
 Drug Info Investigative Discovery agent ICD: N.A. [1]
References
1 Alpha-glactosidase activity of lactobacilli. Appl Microbiol. 1973 Nov;26(5):783-8.

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