Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME2085)
DME Name Cytochrome P450 107W1 (cyp107), Streptomyces avermitilis
Synonyms Cytochrome P450 family 107 subfamily W member 1; Cytochrome P450 monooxygenase 107W1; Narbomycin C-12 hydroxylase 107W1; Pikromycin synthase CYP107W1
Gene Name pikC
UniProt ID
PIKC_STRVZ
EC Number    EC: 1.14.15.11     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Iron-sulfur protein donor oxidoreductase
EC: 1.14.15.11
Lineage    Species: Streptomyces avermitilis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Streptomycetales
Family: Streptomycetaceae
Genus: Streptomyces
Species: Streptomyces avermitilis
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MRRTQQGTTASPPVLDLGALGQDFAADPYPTYARLRAEGPAHRVRTPEGDEVWLVVGYDR
ARAVLADPRFSKDWRNSTTPLTEAEAALNHNMLESDPPRHTRLRKLVAREFTMRRVELLR
PRVQEIVDGLVDAMLAAPDGRADLMESLAWPLPITVISELLGVPEPDRAAFRVWTDAFVF
PDDPAQAQTAMAEMSGYLSRLIDSKRGQDGEDLLSALVRTSDEDGSRLTSEELLGMAHIL
LVAGHETTVNLIANGMYALLSHPDQLAALRADMTLLDGAVEEMLRYEGPVESATYRFPVE
PVDLDGTVIPAGDTVLVVLADAHRTPERFPDPHRFDIRRDTAGHLAFGHGIHFCIGAPLA
RLEARIAVRALLERCPDLALDVSPGELVWYPNPMIRGLKALPIRWRRGREAGRRTG
Structure
2BVJ ; 2C6H ; 2CA0 ; 2CD8 ; 2VZ7 ; 2VZM ; 2WHW ; 2WI9 ; 3ZK5 ; 3ZPI ; 4B7D ; 4B7S ; 4BF4 ; 4UMZ
Function This enzyme regioselectively hydroxylates C12 of oligomycin C to produce oligomycin A.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Oligomycin C
 Drug Info Investigative Colon cancer ICD11: 2B90 [1], [2]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR004432 Oligomycin C Oligomycin A Oxidation - Hydrolyzationn Oligomycin C [3]
References
1 The metagenome of Caracolus marginella gut microbiome using culture independent approaches and shotgun sequencing. Data Brief. 2017 Nov 22;16:501-505.
2 Structural analysis of the Streptomyces avermitilis CYP107W1-oligomycin A complex and role of the tryptophan 178 residue. Mol Cells. 2016 Mar;39(3):211-6.
3 Functional characterization of CYP107W1 from Streptomyces avermitilis and biosynthesis of macrolide oligomycin A

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