Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN043)
DME Name Albumin (ALB), Homo sapiens
Gene Name ALB
UniProt ID
ALBU_HUMAN
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPF
EDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEP
ERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLF
FAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAV
ARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLK
ECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYAR
RHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFE
QLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVV
LNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTL
SEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV
AASQAALGL
Structure
1AO6 ; 1BJ5 ; 1BKE ; 1BM0 ; 1E78 ; 1E7A ; 1E7B ; 1E7C ; 1E7E ; 1E7F ; 1E7G ; 1E7H ; 1E7I ; 1GNI ; 1GNJ ; 1H9Z ; 1HA2 ; 1HK1 ; 1HK2 ; 1HK3 ; 1HK4 ; 1HK5 ; 1N5U ; 1O9X ; 1TF0 ; 1UOR ; 1YSX ; 2BX8 ; 2BXA ; 2BXB ; 2BXC ; 2BXD ; 2BXE ; 2BXF ; 2BXG ; 2BXH ; 2BXI ; 2BXK ; 2BXL ; 2BXM ; 2BXN ; 2BXO ; 2BXP ; 2BXQ ; 2ESG ; 2I2Z ; 2I30 ; 2N0X ; 2VDB ; 2VUE ; 2VUF ; 2XSI ; 2XVQ ; 2XVU ; 2XVV ; 2XVW ; 2XW0 ; 2XW1 ; 2YDF ; 3A73 ; 3B9L ; 3B9M ; 3CX9 ; 3JQZ ; 3JRY ; 3LU6 ; 3LU7 ; 3LU8 ; 3SQJ ; 3TDL ; 3UIV ; 4BKE ; 4E99 ; 4EMX ; 4G03 ; 4G04 ; 4HGK ; 4HGM ; 4IW1 ; 4IW2 ; 4K2C ; 4K71 ; 4L8U ; 4L9K ; 4L9Q ; 4LA0 ; 4LB2 ; 4LB9 ; 4N0F ; 4N0U ; 4S1Y ; 4Z69 ; 5FUO ; 5GIX ; 5GIY ; 5ID7 ; 5IFO ; 5IJF ; 5UJB ; 5VNW ; 5X52 ; 5YB1 ; 5YOQ ; 5Z0B ; 6A7P ; 6EZQ ; 6HSC ; 6JE7 ; 6L4K ; 6M4R ; 6M58 ; 6M5D ; 6M5E ; 6QIO ; 6QIP ; 6R7S ; 6WUW ; 6XV0 ; 6YG9 ; 6ZL1 ; 7A9C ; 7AAE ; 7AAI ; 7D6J ; 7DJN ; 7DL4 ; 7EEK ; 7FFR ; 7FFS ; 7JWN ; 7OV1 ; 7OV5 ; 7OV6 ; 7QFE ; 7VR0 ; 7VR9 ; 7WOJ ; 7WOK ; 7X7X ; 7Z57 ; 8EW4 ; 8EW7 ; 8EY5 ;
Function Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma. Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner. The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood. The rank order of affinity is zinc > calcium > magnesium. Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli. Does not prevent iron uptake by the bacterial siderophore aerobactin.
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR003251 Delamanid DM-6705 Unclear - Unclear Delamanid [1], [2], [3], [4]
References
1 Pharmacokinetics and metabolism of delamanid, a novel anti-tuberculosis drug, in animals and humans: importance of albumin metabolism in vivo. Drug Metab Dispos. 2015 Aug;43(8):1267-76.
2 Liquid chromatography-tandem mass spectrometry analysis of delamanid and its metabolite in human cerebrospinal fluid using protein precipitation and on-line solid-phase extraction. J Pharm Biomed Anal. 2023 Apr 1;227:115281. doi: 10.1016/j.jpba.2023.115281.
3 Relative bioavailability of delamanid 50?mg tablets dispersed in water in healthy adult volunteers. Br J Clin Pharmacol. 2023 Jan 24. doi: 10.1111/bcp.15672.
4 Assessing Prolongation of the Corrected QT?Interval with Bedaquiline and Delamanid Coadministration to Predict the Cardiac Safety?of Simplified Dosing Regimens. Clin Pharmacol Ther. 2022 Oct;112(4):873-881. doi: 10.1002/cpt.2685.

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