Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN093)
DME Name peroxidase (POD), Bacteroides fragilis
Gene Name POD
Lineage    Species: Bacteroides fragilis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Bacteroidaceae
Genus: Bacteroides
Species: Bacteroides fragilis
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 3 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Guaiacol
 Drug Info Phase 3 Glycosylation disorder ICD11: 5C54 [1]
      Drugs in Phase 2 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Flupirtine
 Drug Info Phase 2 Cancer related pain ICD11: MG30 [2]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR008479 D13223 Flupirtine metabolite 10 Oxidation - Oxidation Flupirtine [2]
MR008482 Flupirtine Flupirtine metabolite 14 Unclear - Unclear Flupirtine [2]
MR003639 Guaiacol Guaiacol Metabolite M1 Unclear - Unclear Guaiacol [1]
MR014190 Isoniazid Isonicotinic acyl-NADH Multi-steps Reaction - Reduction; Oxidation Isoniazid [3]
References
1 Guaiacol oxidation activity of herbivorous land crabs, Chiromantes haematocheir and Chiromantes?dehaani
2 Investigation of the in vitro metabolism of the analgesic flupirtine
3 The tuberculosis prodrug isoniazid bound to activating peroxidases

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