Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN139)
DME Name Adenylosuccinate synthetase (purA), Bacillus subtilis
Gene Name purA
UniProt ID
PURA_BACSU
EC Number    EC: 6.3.4.4     (Click to Show/Hide the Complete EC Tree)
Ligase
Carbon-nitrogen ligase
Other carbon-nitrogen ligases
EC: 6.3.4.4
Lineage    Species: Bacillus subtilis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: .
Phylum: .
Class: .
Order: .
Family: .
Genus: .
Species: Bacillus subtilis
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MSSVVVVGTQWGDEGKGKITDFLSENAEVIARYQGGNNAGHTIKFDGITYKLHLIPSGIF
YKDKTCVIGNGMVVDPKALVTELAYLHERNVSTDNLRISNRAHVILPYHLKLDEVEEERK
GANKIGTTKKGIGPAYMDKAARIGIRIADLLDRDAFAEKLERNLEEKNRLLEKMYETEGF
KLEDILDEYYEYGQQIKKYVCDTSVVLNDALDEGRRVLFEGAQGVMLDIDQGTYPFVTSS
NPVAAVSQSVLVSARPKIKHVVGVSKAYTTRVGDGPFPTELKDEIGDQIREVGREYGTTT
GRPPRVGWFDSVVVRHARRVSGITDLSLNSIDVLAGIETLKICVRYRYKGEIIEEFPASL
KALAECEPVYEEMPGWTEDITGAKSLSELPENARHYLERVSQLTGIPLSIFSVGPDRSQT
NVLRSVYRAN
Function Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Xanthine
 Drug Info Phase 1 Obstructive sleep apnea ICD11: 7A41 [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR004027 IMP SAMP Unclear - Unclear Xanthine [1]
References
1 Xanthine metabolism in Bacillus subtilis: characterization of the xpt-pbuX operon and evidence for purine- and nitrogen-controlled expression of genes involved in xanthine salvage and catabolism

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.