Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN166)
DME Name Nicotinamide phosphoribosyltransferase (NAMPT), Homo sapiens
Gene Name NAMPT
UniProt ID
NAMPT_HUMAN
EC Number    EC: 2.4.2.12     (Click to Show/Hide the Complete EC Tree)
Transferase
Glycosyltransferases
Pentosyltransferase
EC: 2.4.2.12
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFY
GLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVP
EGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS
GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGY
SVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV
SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINT
LQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVAD
PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNA
QLNIELEAAHH
Structure
2E5B ; 2E5C ; 2E5D ; 2GVG ; 2GVJ ; 3DGR ; 3DHD ; 3DHF ; 3DKJ ; 3DKL ; 4JNM ; 4JR5 ; 4KFN ; 4KFO ; 4KFP ; 4L4L ; 4L4M ; 4LTS ; 4LV9 ; 4LVA ; 4LVB ; 4LVD ; 4LVF ; 4LVG ; 4LWW ; 4M6P ; 4M6Q ; 4N9B ; 4N9C ; 4N9D ; 4N9E ; 4O0Z ; 4O10 ; 4O12 ; 4O13 ; 4O14 ; 4O15 ; 4O16 ; 4O17 ; 4O18 ; 4O19 ; 4O1A ; 4O1B ; 4O1C ; 4O1D ; 4O28 ; 4WQ6 ; 5KIT ; 5LX3 ; 5LX5 ; 5NSD ; 5U2M ; 5U2N ; 5UPE ; 5UPF ; 5WI0 ; 5WI1 ; 6ATB ; 6AZJ ; 6B75 ; 6B76 ; 6E68 ; 6PEB ; 6TA0 ; 6TA2 ; 6TAC ; 7ENQ ; 7PPE ; 7PPF ; 7PPG ; 7PPH ; 7PPI ; 8DSC ; 8DSD ; 8DSE ; 8DSH ; 8DSI ; 8DTJ
Function Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity).
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
D-ribosylnicotinate
 Drug Info Investigative Discovery agent ICD: N.A. [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR012864 Nicotinamide (NAM) NMN Unclear - Unclear D-ribosylnicotinate [1]
MR012864 Nicotinamide (NAM) NMN Unclear - Unclear D-ribosylnicotinate [1]
References
1 Nicotinamide riboside and nicotinic acid riboside salvage in fungi and mammals. Quantitative basis for Urh1 and purine nucleoside phosphorylase function in NAD+ metabolism

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