Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN239)
DME Name Acyl-CoA dehydrogenase (ACAD), Bacteroides fragilis
Gene Name ACAD
Lineage    Species: Bacteroides fragilis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Bacteroidaceae
Genus: Bacteroides
Species: Bacteroides fragilis
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          2 Drugs
Ibuprofen
 Drug Info Approved Anaesthesia ICD11: 8E22 [1]
3,4-Dihydroxycinnamic Acid
 Drug Info Phase 4 Thrombocytopenia ICD11: 3B64 [2]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR009194 3,4-Dihydroxycinnamic Acid 3-(Dihydroxyphenyl)propanoic acid Reduction - Reduction 3,4-Dihydroxycinnamic Acid [3], [2]
MR009201 DHFA FA Unclear - Unclear 3,4-Dihydroxycinnamic Acid [2]
MR004640 Ibuprofen Metabolite M8 Ibuprofen Metabolite M9 Unclear - Unclear Ibuprofen [1]
References
1 Genetic Characterization of the Ibuprofen-Degradative Pathway of Rhizorhabdus wittichii MPO218
2 Metabolism of caffeic acid by isolated rat hepatocytes and subcellular fractions
3 In vitro catabolism of 3',4'-dihydroxycinnamic acid by human colonic microbiota

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