General Information of DME (ID: DMEN290)
DME Name 3-hydroxysteriod dehydrogenase (3HSD), Homo sapiens
Gene Name 3HSD
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Tibolone
Drug Info Phase 4 Depression ICD11: 6A71 [1], [2], [3]
      Drugs in Phase 2 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
TOK-001
Drug Info Phase 2 Prostate cancer ICD11: 2C82 [4]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR006187 Tibolone 3alpha-OH-tibolone Oxidation - Hydrolyzationn Tibolone [1], [2], [3]
References
1 Sulfation of tibolone and tibolone metabolites by expressed human cytosolic sulfotransferases. J Steroid Biochem Mol Biol. 2004 Apr;88(4-5):383-91.
2 Sulfation of tibolone metabolites by human postmenopausal liver and small intestinal sulfotransferases (SULTs). Steroids. 2006 May;71(5):343-51.
3 Antioxidant effect of the active metabolites of tibolone
4 Steroidogenic Metabolism of Galeterone Reveals a Diversity of Biochemical Activities

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