Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DMEN302)
DME Name UDP-glucuronosyltransferase 2B1 (Ugt2b1), Rattus norvegicus
Gene Name Ugt2b1
UniProt ID
UD2B1_RAT
EC Number    EC: 2.4.1.17     (Click to Show/Hide the Complete EC Tree)
Transferase
Glycosyltransferases
Hexosyltransferase
EC: 2.4.1.17
Lineage    Species: Rattus norvegicus     (Click to Show/Hide the Complete Species Lineage)
Kingdom: .
Phylum: .
Class: .
Order: .
Family: .
Genus: .
Species: Rattus norvegicus
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MSMKQTSVFLLIQLICYFRPGACGKVLVWPTEYSHWINIKIILNELAQRGHEVTVLVSSA
SILIEPTKESSINFEIYSVPLSKSDLEYSFAKWIDEWTRDFETLSIWTYYSKMQKVFNEY
SDVVENLCKALIWNKSLMKKLQGSQFDVILADAVGPCGELLAELLKTPLVYSLRFCPGYR
CEKFSGGLPLPPSYVPVVLSELSDRMTFVERVKNMLQMLYFDFWFQPFKEKSWSQFYSDV
LGRPTTLTEMMGKADIWLIRTFWDLEFPHPFLPNFDFVGGLHCKPAKPLPREMEEFVQSS
GEHGVVVFSLGSMVKNLTEEKANVVASALAQIPQKVVWRFDGKKPDTLGSNTRLYKWIPQ
NDLLGHPKTKAFVAHGGTNGIYEAIYHGIPIVGIPLFADQPDNINHMVAKGAAVRVDFSI
LSTTGLLTALKIVMNDPSYKENAMRLSRIHHDQPVKPLDRAVFWIEYVMRHKGAKHLRST
LHDLSWFQYHSLDVIGFLLLCVVGVVFIITKFCLFCCRKTANMGKKKKE
Function UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile . Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds . Catalyzes the glucuronidation of the endogenous estrogen hormone estradiol .
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Osilodrostat
 Drug Info Approved Cushing syndrome ICD11: 5A70 [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Tetramethylbutylphenol
 Drug Info Investigative Discovery agent ICD: N.A. [2]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR005903 4-tert-Octylcatechol 4-tert-Octylcatechol-glucuronide Unclear - Unclear Tetramethylbutylphenol [2]
MR005905 Hydroxyl-tert-octylphenol Hydroxyl-tert-octylphenol-glucuronide Unclear - Unclear Tetramethylbutylphenol [2]
MR005906 Tetramethylbutylphenol 4-tert-Octylphenol-glucuronide Unclear - Unclear Tetramethylbutylphenol [2]
References
1 DrugBank(Pharmacology-Metabolism):Osilodrostat
2 Differential metabolism of 4-n- and 4-tert-octylphenols in perfused rat liver

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